丹参酮胶囊联合奥硝唑治疗口腔颌面部炎症的临床研究  

Clinical study on Danshentong Capsules combined with ornidazole in treatment of oral and maxillofacial inflammation

作　　者：米磊[1] 刘怀勤[1] 高宇[1] 

机构地区：[1]榆林市第一医院口腔科,陕西榆林719000

出　　处：《现代药物与临床》2016年第10期1640-1643,共4页Drugs & Clinic

摘　　要：目的探讨丹参酮胶囊联合奥硝唑治疗口腔颌面部炎症的临床疗效。方法选取2015年2月—2016年2月在榆林市第一医院接受治疗的口腔颌面部炎症患者94例,随机分组法分为对照组和治疗组,每组各47例。对照组口服奥硝唑片,2片/次,2次/d。治疗组在对照组基础上口服丹参酮胶囊,4粒/次,3次/d。两组患者均治疗5 d。观察两组的临床疗效,比较两组的血液流变学和血清炎性因子的情况。结果治疗后,对照组和治疗组的总有效率分别为82.98%、95.74%,两组比较差异有统计学意义(P<0.05)。治疗后,两组红细胞沉降率(ESR)、全血黏度、纤维蛋白原(FIB)、血浆黏度均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的降低程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-γ(TNF-γ)水平均显著降低,而白细胞介素-4(IL-4)水平明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论丹参酮胶囊联合奥硝唑治疗口腔颌面部炎症具有较好的临床疗效,可改善血液流变学,降低机体炎症性反应,具有一定的临床推广应用价值。Objective To explore the clinical effect of Danshentong Capsules combined with ornidazole in treatment of oral and maxillofacial inflammation. Methods Patients（94 cases） with oral and maxillofacial inflammation in the First Hospital of Yulin from February 2015 to February 2016 were randomly divided into the control and treatment groups, and each group had 47 cases. Patients in the control group were po administered with Ornidazole Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Danshentong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and hemorheology and serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.98% and 95.74%, respectively, and there was difference between two groups（P〈0.05）. After treatment, ESR, whole blood viscosity, FIB, and plasma viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the levels of CRP, IL-6, and TNF-γ in two groups were significantly decreased, but the levels of IL-4 in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Danshentong Capsules combined with ornidazole has clinical curative effect in treatment of oral and maxillofacial inflammation, and can improve hemorheology, decrease inflammatory reactions, which has a certain clinical application value.

关 键 词：丹参酮胶囊 奥硝唑片 口腔颌面部炎症 血液流变学 血清炎性因子 

分 类 号：R988.2[医药卫生—药品]