超声心动图评价外源性硫化氢对糖尿病心肌病大鼠心功能的影响  

Effect Evaluation of Exogenous H_2S on Cardiac Function in Rats with Diabetic Cardiomyopathy by Echocardiography

作　　者：房城[1] 郑秀茜[1] 刘永武[1] 赵良友[1] 刘树民[1] 

机构地区：[1]黑龙江中医药大学药物安全性评价中心,哈尔滨150040

出　　处：《中国药师》2016年第11期2073-2075,共3页China Pharmacist

基　　金：黑龙江省青年科学基金项目(编号:QC2014C116)

摘　　要：目的:采用超声心动图来检测外源性硫化氢(H_2S)对糖尿病大鼠心功能的影响。方法:将SD大鼠随机分为对照组、模型组和治疗组,每组5只。一次性腹腔注射链脲佐菌素(STZ)制备糖尿病大鼠模型。治疗组腹腔注射Na HS,对照组和模型组给予等量生理盐水。12周后通过超声心动图进行检测。结果:与模型组比较,治疗组的收缩期室间隔厚度(IVSd)、舒张期室间隔厚度(IVSs)、收缩期左室内径(LVIDs)和舒张期左室后壁厚度(LVPWd)明显降低(P<0.01),收缩期左室后壁厚度(LVPWs)明显降低(P<0.05),治疗组心功能指标射血分数(EF)和缩短分数(FS)明显升高(P<0.01)。结论:通过超声心动图证明,外源性H_2S能够有效减少糖尿病心肌病大鼠心肌重构,改善糖尿病心肌病大鼠心功能。Objective： To evaluate the effect of exogenous H2S on cardiac function in rats with diabetic eardiomyopathy by echo- cardiography. Methods： SD rats were randomly divided into the normal control group, the model group and the treatment group （5 ones in each）. Diabetic eardiomyopathy models were made by single intraperitoneal injection of streptozotoein （STZ）. The treatment group was given intraperitoneal injection of NariS, the control group and the model group was both given intraperitoneal injection of saline solution. The effect of exogenous H2S on the cardiac function in the rats was evaluated by eehoeardiography after 12 weeks. Resuits： Compared with those in the model group, IVSd, IVSs, LVIDs and LVPWd were much smaller in the treatment group （P 〈 0.01 ）, LVPWs was much smaller as well （P 〈 0.05 ）, and EF and FS were improved significantly （P 〈 0.01 ）. Conclusion： Exogenous H2 S can improve the heart function and reduce the myocardial remodeling in rats with diabetic cardiomyopathy.

关 键 词：外源性硫化氢 超声心动图 糖尿病心肌病 

分 类 号：R965.1[医药卫生—药理学]