肿瘤坏死因子α基因-308位点多态性与寻常痤疮相关性的Meta分析  

Association between tumor necrosis factor α-308 G/A polymorphism and acne vulgaris：a meta-analysis

作　　者：仓田[1] 王宝玺[1] 龚向东[1] 李奇[1] 徐浩翔[1] 刘毅[1] Cang Tian Wang Baoxi Gong Xiangdong Li Qi Xu Haoxiang Liu Yi(Department of Dermatology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院皮肤科第二作者现在中国医学科学院北京协和医学院整形外科医院皮肤科,南京210042

出　　处：《中华皮肤科杂志》2016年第11期824-826,共3页Chinese Journal of Dermatology

基　　金：国家自然科学基金（81472905）

摘　　要：目的：应用Meta分析探讨肿瘤坏死因子α（TNF-α）-308位点G/A多态性与寻常痤疮易感性的相关性。方法检索PUBMED、EMBASE和CNKI数据库自建库以来（分别是1948、1974、1994年）至2015年8月20日收录的相关文献，按照纳入与排除标准筛选出关于TNF-α基因-308位点多态性与寻常痤疮相关性的病例-对照研究文献，进行文献质量评价和数据提取，采用Stata12.0软件进行分析。结果共纳入7项研究，包括986例痤疮患者和1074例健康对照。总体分析未发现TNF-α-308位点G/A多态性和寻常痤疮有显著相关性。结论 TNF-α-308位点G/A多态性与寻常痤疮无显著相关性。Objective To assess the association between tumor necrosis factor α（TNF-α）-308 G/A polymorphism and the susceptibility to acne vulgaris by using a meta-analysis. Methods Relevant literature was searched in the PubMed（1948-August 20, 2015）, Embase（1974-August 20, 2015）and CNKI（1994-August 20, 2015）databases. According to the inclusion and exclusion criteria, case-control studies on the association between the TNF-α-308 G/A polymorphism and acne vulgaris were selected. Then, the quality of studies was evaluated, data were extracted, and statistical analysis was done by using Stata 12.0 software. Results Finally, 7 eligible studies were included in this meta-analysis, which comprised 986 patients with acne vulgaris and 1 074 healthy controls. No significant association was observed between the TNF-α-308 G/A polymorphism and acne vulgaris. Conclusion There is no significant association between TNF-α-308 G/A polymorphism and acne vulgaris.

关 键 词：寻常痤疮 肿瘤坏死因子Α 多态性 单核苷酸 META分析 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]