力学过载对成骨细胞损伤及中药修复的研究进展  

Research progress of mechanical overload on osteoblast injury and its repair by traditional Chinese medicine

作　　者：刘迎节[1,2] 李瑞欣[2] 赵滨[2,3] 李昊[2] 李军[2] 苏卫华[2] 郝宝辉 徐云强[1] 张西正[2] 

机构地区：[1]天津医科大学总医院骨科,天津300052 [2]军事医学科学院卫生装备研究所,天津300161 [3]吉林大学白求恩第一医院骨科,长春130000

出　　处：《医用生物力学》2016年第5期456-460,466,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11432016;31370942;31470935)

摘　　要：骨的生长代谢由成骨细胞的成骨及破骨细胞的吸收共同控制,而成骨细胞在成骨过程中起主要作用。过载影响成骨细胞的增殖与分化,其加载方式、强度、持续时间等因素都可改变成骨细胞的生物特性,进而影响成骨细胞的功能活性。而过载引起成骨细胞应答的机制还处于探索阶段,需要进一步深入研究。大量实验证明,中药淫羊藿苷促进成骨细胞增殖及分化,一定浓度的淫羊藿苷对骨损伤修复起重要作用。综述骨细胞对过载刺激后的反应及淫羊藿苷对成骨细胞的损伤修复。The growth and metabolism of bone are controlled by osteogenesis of osteoblasts and absorption of os- teoclasts, and osteoblasts play a main role in the process of osteogenesis. Overload will affect proliferation and differentiation of osteoblasts, while the loading mode, intensity, duration and other factors can change the biologi- cal properties of osteoblasts and further affect the functional activity of osteoblasts. However, the mechanism of osteoblast response to overload is still at the exploratory stage and needs in-depth study. Numerous studies have demonstrated that icariin, a kind of Chinese medicine, can promote proliferation and differentiation of osteoblasts, and icariin with a certain concentration plays an important role in the repair of osteoblast injuries. In this paper, the responses of osteoblasts to overload stimulation and repair of osteoblast injuries by icariin were summarized.

关 键 词：过载 成骨细胞 细胞应答 淫羊藿苷 

分 类 号：R318.01[医药卫生—生物医学工程]