基于模拟肺的比例辅助通气呼吸力学研究  

Research on Respiratory Mechanics of Proportional Assist Ventilation Based on Simulated Lung

作　　者：陈维波[1] 王武[1] 项蒙[1] 金珏斌 陈洁[1] 潘景业[1] Chen Weibo Wang Wu Xiang Meng Jin Juebin Chen Jie Pan Jingye.(Pan Jingye. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Zhejiang 325000, Chin)

机构地区：[1]温州医科大学附属第一医院,浙江温州325000

出　　处：《航天医学与医学工程》2016年第5期329-333,共5页Space Medicine & Medical Engineering

基　　金：浙江省医学创新学科(危重创伤救治学);温州市科技局科技项目(Y20140429)

摘　　要：目的研究比例辅助通气(PAV)估算患者呼吸系统力学参数的有效率及PAV较其它通气模式可能具有的优势。方法以模拟肺作为实验平台,研究PAV模式下呼吸机对146例呼吸系统顺应性(C)和146例气阻(R)估算的有效率,以及206例不同参数的PAV与压力辅助通气(PSV)及双水平正压通气(Bi Level)在呼吸力学上的差别。结果相对于传统Younes方法,本研究对C估值的决定系数由0.820提高到0.943,R估值的决定系数由0.489提高到0.890;PAV较PSV和Bilevel在气道平均压和吸气时间上有显著优势。结论 PAV实现了实时的呼吸系统力学参数定量估计且利于肺保护通气。Objective To study the effectiveness of the proportional assist ventilation（ PAV） in estimating the mechanical parameters of respiratory system and the possible advantages of PAV compared with other ventilation modes. Methods Based on simulated lung,the efficiency of 146 cases of respiratory compliance and 146 cases of resistance was studied under the PAV model,which was estimated by the ventilator. The differences in respiratory mechanics between PAV,PSV and Bi Level in 206 cases with different parameters were also studied. Results Relative to the Younes＇ method,the results of this research showed that the coefficient of determination was increased to 0. 943 from 0. 820 on compliance＇s estimation,and it was increased to 0. 890 from 0. 489 on resistance＇s estimation. Compared with PSV and Bi Level,PAV had a significant advantage in the mean airway pressure and inspiratory time. Conclusion The quantitative estimation of respiratory system＇s mechanical parameters is realized by PAV in real time. PAV will contribute to lung＇s protective ventilation.

关 键 词：模拟肺 比例辅助通气 呼吸力学 顺应性 气阻 

分 类 号：R318.6[医药卫生—生物医学工程]