骨转移癌患者跟骨骨密度与骨形成标志物的关系  

Detection and correlation study of calcaneal BMD and bone formation markers in patients with bone metastasis

作　　者：胡泊[1] 朱冉[1] 王卿[1] 刘荣志[1] 袁海胜[2] 马长德[3] 

机构地区：[1]南阳医学高等专科学校基础医学部,河南南阳473061 [2]南阳医学高等专科学校第一附属医院骨科,河南南阳473058 [3]南阳理工学院医学实验中心,河南南阳473004

出　　处：《广东医学》2016年第20期3037-3040,共4页Guangdong Medical Journal

基　　金：科技部科技基础性工作专项(编号:2015FY111700)

摘　　要：目的探讨骨转移癌患者跟骨骨密度(BMD)与血清骨钙素(BGP)、骨性碱性磷酸酶(B-ALP)、I型前胶原氨基端前肽(PINP)水平的相关性。方法采用定量超声法、化学发光免疫分析法(CLIA法)、酶联免疫法(ELISA法)测定101例骨转移癌患者跟骨BMD以及血清BGP、B-ALP、PINP水平,并以101例健康人群作对照组,然后按性别分组,分别进行性别内的患病组与对照组比较。结果骨转移癌患者跟骨BMD T值、Z值下降(P<0.05),与年龄呈负相关、与体质量呈正相关(P<0.05),女性患者Z值还与身高、BMI正相关(P<0.05);血清BGP、B-ALP、PINP水平升高(P<0.05),与BMD T值、Z值负相关(P<0.05)(女性患病组Z值与BGP无相关关系)。结论骨转移癌患者跟骨BMD下降,骨形成标志物BGP、B-ALP、PINP升高,两者存在一定相关性;跟骨BMD与骨形成标志物联合检测,可较好地评估患者局部及整体骨量变化。Objective To investigate the level of calcaneat bone mineral density （BMD） and three kinds of bone formation markers, including osteocalcin （BGP）, bone alkaline phophatase （B -ALP）, and aminoterminal propeptide of type I procollagen （PINP）, patients with bone metastasis; and to discuss their relevance. Methods... The quantitative ultrasound method, chemiluminesent lmmunoassay assay （CLIA） and enzyme linked immunosorbent assay （ELISA） were used to determine T value and Z value of the calcaneal BMD, and BGP, B - ALP, PINP in serum of 101 cases with bone metastasis. The correlations were analyzed. Results The BMD T and Z values of patients with bone metastasis were significantly reduced （P 〈 0. 05 ）, and negatively correlated to age, and positively correlated＇ to body mass （P 〈 0. 05）. The Z value was significantly negatively correlated to height and BMI in the female patients （P 〈 0. 05 ）. The levels of BGP, B - ALP and PINP in serum of disease group were significantly increased （P 〈 0. 05 ） ; and significantly negatively correlated to BMD T and Z values （P 〈0. 05, except for Z value and BGP in female）. Conclusion The calcaneal BMD of patients with bone metastasis decreases, with increase in the levels of bone formation markers as BGP, B - ALP, and PINP. The union detection can be used for accurate assessment the changes of the local and general of BMD.

关 键 词：骨转移癌 骨密度 骨钙素 骨性碱性磷酸酶 I型前胶原氨基端前肽 

分 类 号：R714.14[医药卫生—妇产科学]