淋巴细胞免疫与非免疫治疗封闭抗体缺乏致胚胎停育效果观察  

Therapeutic effect of lymphocyte immunotherapy and non-lymphocyte immunotherapy on early pregnant failure induced by the absence of blocking antibody

作　　者：赵冬梅[1] 耿旭景[1] 谭丽[1] 马丽影[1] 项云改[1] 张丹[1] 

机构地区：[1]郑州大学第二附属医院生殖中心,郑州450014

出　　处：《中华实用诊断与治疗杂志》2016年第11期1082-1084,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省医学科技攻关计划项目(201303085)

摘　　要：目的分析胚胎停育的原因,比较封闭抗体缺乏致胚胎停育的淋巴细胞免疫治疗与非免疫治疗的效果。方法102例早期胚胎停育患者,选择其中复发性流产2次以上、封闭抗体缺乏、无子宫发育异常和染色体异常、男方精液无异常患者58例,根据男方传染病检验结果和自愿选择治疗方案原则分为免疫治疗组30例和非免疫治疗组28例,非免疫治疗组给予促排卵、黄体支持及辅助生殖技术等治疗,免疫治疗组在非免疫治疗组治疗基础上,抽取患者丈夫(或健康第三方)静脉血提取淋巴细胞皮下注射,比较2组妊娠结局。结果 102例中胚胎染色体异常64例(62.74%),封闭抗体缺乏81例(79.41%),多囊卵巢综合征60例(58.82%);免疫治疗组封闭抗体转阳率为76.67%,妊娠率为80.00%;非免疫治疗组妊娠率为78.57%,2组妊娠率比较差异无统计学意义(P>0.05)。结论胚胎染色体异常是胚胎停育的主要原因;淋巴细胞免疫治疗与非免疫方法治疗封闭抗体缺乏所致胚胎停育均可获得理想妊娠率。Objective To observe the causes of early pregnant failure and compare the therapeutic effects between lymphocyte immunotherapy and non-lymphocyte immunotherapy on the early pregnant failure induced by absence of blocking antibody. Methods In 102 patients with early pregnant failure, 58 patients with more than twice recurrent abortion, absence of blocking antibody, no anatomical cacogenesis of uterus, no chromosome abnormality and no dysspermatism, were divided into lymphocyte immunotherapy group （n= 30） and non-lymphocyte immunotherapy group （n= 28） according to the infectious disease inspection results of the patients＇ husbands and the patients＇ choices. Non-lymphocyte immunotherapy group received ovarian stimulation, luteal support and assisted reproductive technology, besides which lymphocyte immunotherapy group received subcutaneous injeetion of lymphoeytes from the venous blood of husband or health person. The pregnancy outcomes were compared between two groups. Results In 102 patients, there were 64 patients with chromosome abnormality （62.74%）, 81 patients with absence of bloeking antibody （79.41%）, and 60 patients with polycystic ovary syndrome （58. 82%）. In lymphocyte immunotherapy group, the positive rate of blocking antibody was 76.67%, and the pregnancy rate was 80. 00%. In non-lymphocyte immunotherapy group, the pregnancy rate was 78. 57%, showing no significant difference in pregnancy rate between two groups （P〉0.05）. Conclusion Chromosome abnormality is the main cause of early pregnant failure. Both lymphocyte immunotherapy and non-lymphocyte immunotherapy can acquire ideal pregnancy outcomes.

关 键 词：胚胎停育 封闭抗体 多囊卵巢综合征 淋巴细胞免疫治疗 

分 类 号：R714.21[医药卫生—妇产科学]