瞬态诱发性耳声发射技术联合自动听性脑干反应检查筛查高危新生儿听力受损的价值  

Value of transient evoked otoacoustic emission technology combined with automated auditory brainstem response checks to screening hearing impair in high-risk neonates

作　　者：孙志宏 孙黎晓 吴红丽 

机构地区：[1]平顶山市第二人民医院耳鼻喉科,河南平顶山467000

出　　处：《中华实用诊断与治疗杂志》2016年第11期1101-1102,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省医学会2015年度中青年计划(2015HW052)

摘　　要：目的探讨瞬态诱发性耳声发射（transient evoked otoacoustic emission，TEOAE）技术联合自动听性脑干反应（automated auditory brainstem response，AABR）在高危新生儿听力受损筛查中的价值。方法391例有听力损害高危因素新生儿，于出生后3～20d行听力损害检查（初筛），其中双耳TEOAE检查均未通过者193例（386耳）为未通过组，均通过者198例（396耳）为通过组。分别于出生后42d和3个月时再次行听力损害检查（第1、2次复筛），比较TEOAE法、AABR法、TEOAE联合AABR筛查（联合法）3种方式以及2组初筛、复筛的通过率。结果TEOAE法在初筛及第1、2次复筛中的通过率分别为50．64％、87．60％、90．28％，AABR法分别为77．62％、85．04％和96．55％，联合法分别为43．09％、83．76％和89．13％，联合法筛查通过率低于TEOAE、AABR，差异有统计学意义（P〈0．05）；未通过组初筛及第1、2次复筛应用联合法的通过率分别为0、77．460A、81．61％％，通过组分别为85．10％、89．90％、96．46％，通过组应用联合法初筛及第1、2次复筛通过率高于未通过组（P〈0．05）。结论TEOAE联合AABR用于高危新生儿听力受损筛查，可降低假阳性率和漏诊率。Objective To investigate the value of transient evoked otoacoustic emission （TEOAE） technology and automated auditory brainstem response （AABR） to screening hearing impair in high-risk neonates. Methods A total of 391 neonates with high-risk hearing impair received TEOAE 3 to 20 days after birth （primary screen）, in which neither ears of 193 neonates passed the screen （no-passing group） and both ears of 198 neonates passed the screen （passing group）. Both two groups were rescreened 42 clays and 3 months after birth. The results of TEOAE, AABR and TEOAE plus AABR were compared and their passing rates were observed at different time points in both groups. Results The passing rates of TEOAE were 50.64%, 87.60% and 90.28%, and of AABR were 77.62%, 85.04% and 96.55% at primary screen, 42 days and 3 months, significantly higher than those of TEOAE plus AABR （43. 09%, 83. 76%, 89.13%） respectively （P〈0.05）. The passing rates of TEOAE plus AABR at primary screen, 42 days and 3 months were significantly lower in no-passing group （0, 77.46%, 81.61%） than those in passing group （85. 10%, 89. 90%, 96.46%） （P〈0.05）. Conclusion TEOAE plus AABR can reduce the false positive rate and omission diagnostic rate of high-risk neonatal hearing impair.

关 键 词：高危新生儿 听力筛查 瞬态诱发性耳声发射技术 自动听性脑干反应 

分 类 号：R764.04[医药卫生—耳鼻咽喉科]