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机构地区:[1]四川省医学科学院.四川省人民医院风湿免疫科,四川成都610072
出 处:《实用医院临床杂志》2016年第6期68-70,共3页Practical Journal of Clinical Medicine
摘 要:目的对比非布司他与别嘌醇在痛风治疗中降尿酸的有效性和安全性。方法 2011年11月至2014年12月我院风湿免疫科就诊的90例痛风患者,分为非布司他40 mg组,非布司他80 mg组和别嘌醇组各30例,比较降尿酸的效果和不良事件发生情况。结果各组患者的尿酸水平在治疗1月后与基线比较均明显降低(P<0.05),非布司他80 mg组与别嘌醇组比较,尿酸水平在第1、2、3、6月明显降低;与非布司他40 mg组比较,尿酸水平在第1、5、6月明显降低(P<0.05)。非布司他40 mg组与别嘌醇组比较,各时点尿酸水平差异均无统计学意义(P>0.05)。两非布司他组的肝功损害、高脂血症和痛风发作的发生率高于别嘌醇组(P<0.05)。结论在各器官功能正常的患者中,非布司他治疗有效性和安全性更易被接受。Objective To evaluate and compare the efficacy and safety of two xanthine oxidase inhibitor:febuxostat and allo-purinol in Chinese gout patients.Methods Ninety gout patients treated in our department form November 2011 to December 2014 were selected and divided into three groups:febuxostat 40 mg qd,febuxostat 80 mg qd and allopurinol 0.1 g tid,30 patients in each group. The effect of reducing uric acid and adverse events were compared.Results The levels of serum UA in all three groups were reduced when compared to basic line after one month of treatment (P〈0.05).In the febuxostat 80 mg qd group,serum uric acid levels were significantly decreased in the 1 st,2 nd,3rd and 6 th month and in 1 st,5 th and 6 th month after treatment when compared to the allo-purinol group and the febuxostat 40 mg qd group,respectively (P〈0.05).There was no significant difference in serum uric acid be-tween febuxostat 40 mg qd group and allopurinol group at different time points ( P 〉0.05) .However,the incidence of abnormal liver function,hyperlipidemia and gout flare was also higher in febuxostat groups when compared to the allopurinol group (P〈0.05).Con-clusion Febuxostat 40 mg qd has a better efficacy and acceptable safety concerns than the other dose and allopurinol in gout patients with normal organ function.
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