膀胱内注射肉毒毒素对膀胱疼痛综合征疼痛程度影响的Meta分析  

Effect of Intravesical Botulinum Toxin Injection on Pain of Bladder Pain Syndrome: A Meta-analysis

作　　者：张杰[1] 王强[2,3] 王增春[2,3] 任自刚[2,3] 熊巍[2,3] 刘海泉[2,3] 王俊杰[2,3] 范婷婷[2,3] 

机构地区：[1]首都医科大学附属北京地坛医院麻醉科,北京市100015 [2]中国康复研究中心北京博爱医院麻醉科,北京市100068 [3]首都医科大学康复医学院,北京市100068

出　　处：《中国康复理论与实践》2016年第10期1222-1226,共5页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的系统评价膀胱内注射肉毒毒素对膀胱疼痛综合征疼痛程度的影响。方法检索Cochrane图书馆、Pub Med、Web of Science、Embase、Springer、Wiley、Science Direct、OVID数据库,搜集膀胱内注射肉毒毒素治疗膀胱疼痛综合征的随机对照试验。由两位研究者根据纳入与排除标准筛选试验,提取资料并进行质量评价后,取治疗前、后视觉模拟评分值,利用RevMan 5.2软件进行Meta分析。结果最终筛选出5篇符合条件的文献,共纳入218例患者,其中对照组91例,膀胱内注射肉毒毒素组127例。Meta分析结果显示膀胱内注射肉毒毒素组对疼痛的缓解程度优于对照组。结论膀胱内注射肉毒毒素能够缓解膀胱疼痛综合征的疼痛程度。Objective To systemically evaluate the effect of intravesical Botulinum toxin on pain of patientspain syndrom. Methods The following databases as Cochrane Library, Pub Med, Web of Science, Embase, Springer, Wiley, Science Direct, OVID were searched to collect the randomized controlled trials（RCTs） with the treatment of intravesical Botulinum toxin vs. 0.9% sodium chloride for patients with bladder pain syndrome. Two reviewers screened the trials according to the inclusion and exclusion criterias, extracted the data, assessed the quality, and the changes of Visual Analogue Scales（VAS） before and after treatment were used to conduct Meta analysis with Rev Man5.2software. Results Five studies were included with a total of 218 patients, there were 127 cases in intravesical Botulinum toxin group and 91 cases in 0.9% sodium chloride group. Meta analysis showed that the pain relief effect of intravesical Botulinum toxin was better than that of0.9% sodium chloride. Conclusion Intravesical Botulinum toxin can relieve the pain of patients with bladder pain syndrome.

关 键 词：膀胱疼痛综合征 肉毒毒素 膀胱注射 随机对照试验 META分析 

分 类 号：R694[医药卫生—泌尿科学]