内包材表面涂布PVA延缓珍珠明目滴眼液冰片的挥发  

Delay volatilization of borneol of Zhenzhumingmu Eye-drop by inner packaging material coated with polyvinyl alcohol

作　　者：郭淑杰[1] 

机构地区：[1]吉林师范大学分院化学系,吉林四平136000

出　　处：《应用化工》2016年第11期2204-2206,共3页Applied Chemical Industry

基　　金：全国教育科学"十五"规划研究课题(FHB040043-JLSDFY-001)

摘　　要：利用聚乙烯醇(PVA)良好的气体阻隔性,将其均匀涂布于珍珠明目滴眼液内包材表面,延缓冰片的挥发,控制其有效含量。通过正交实验法考察涂布液浓度、涂布次数和干燥方式的影响,经过加速稳定性4个月实验后,采用气相色谱法测定药液冰片含量。结果表明,最佳涂布工艺为:30%的PVA溶液重复涂布3次后冷冻至完全干燥。加速稳定性4个月后,外观与澄明度良好,冰片含量>0.20 mg/m L,符合国家标准规定,且无新的杂质出现。To delay volatilization of borneol and control its effective content , inner packaging material of Zhenzhumingmu Eye-drop coated with polyvinyl alcohol which have excellent gas barrier properties .Or-thogonal test method was used to study the effect of coating liquid contents , coating times and drying types.The content of borneol was determined by GC through accelerated stability test after four months . Result showed that the optimum conditions were as follows：30%polyvinyl alcohol was repeatedly coated three times ,completelyfroze drying subsequently .Appearance ,transparency and borneol content of coated Eye-drop were more than 0.20 mg/mL,meet the demand of national standard ,and none new impurities appeared through accelerated stability test after four months .

关 键 词：珍珠明目滴眼液 冰片挥发 涂布 

分 类 号：TQ325.9[化学工程—合成树脂塑料工业]