益母草注射液生物碱单体配伍对离体子宫收缩活动的影响  

Effect of Alkaloid Monomer of Yimucao Injection on Isolated Smooth Muscle of Uterus

作　　者：代良萍 谢晓芳[1] 孙晨[1] 敖慧[1] 董艳红[1] 彭成[1] 

机构地区：[1]成都中医药大学药学院中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都610075

出　　处：《天然产物研究与开发》2016年第10期1633-1638,共6页Natural Product Research and Development

基　　金：国家自然科学基金人才培养项目(J1310034);成都中医药大学中药基础基地科研训练及科研能力提高项目;中药药理四川省青年基金科技创新研究团队(2014TD0007);中药资源四川省青年科技创新研究团队(2015TD0028)

摘　　要：采用离体子宫模型,通过观察水苏碱、胆碱和葫芦巴碱单独应用以及两两配伍应用(2∶1、1∶1、1∶2)对大鼠及豚鼠正常离体子宫收缩活动的影响。结果表明,3×10-5mol/L水苏碱、胆碱和葫芦巴碱及其两两配伍(1∶1、2∶1、1∶2)对正常大鼠离体子宫收缩活动无明显影响;对豚鼠离体子宫收缩活动有兴奋作用,主要是通过增加其收缩幅度达到,同时减少收缩频率。水苏碱、胆碱和葫芦巴碱对子宫活动呈现兴奋作用,效应与动物种属有关,且对子宫的作用不存在协同或拮抗作用。To study the effect of alkaloid constituents extracted from Yimucao Injection （YMCI） on uterine contractile activity,isolated uterus were prepared and treated by stachydrine, choline and trigonelline respectively or compatibilities between each two constituents at ratios of 2： 1,1 ： 1,1 ： 2. Peak area （ PA）, frequency （ Fre）, mean contractile force （MCF） and amplitude （Amp） were monitored. The results showed that the 3 × 10 -5 mol/L stachydrine, choline and trigoneUine and its two compatibility （ 1： 1,2： 1 and 1： 2） had no obvious effect on uterine contractions in vitro of normal rats. But they can induce stimulate effects on the uterine contraction of the guinea pigs, which is mainly by increasing its shrinkage rate and at the same time reducing the frequency of contraction. Stachydrine, choline and trigonelline can have excitation on uterine activity, which is related to animal species, and there is no synergistic effect or antagonism on uterine.

关 键 词：水苏碱 胆碱 胡芦巴碱 离体子宫 配伍 

分 类 号：R285.5[医药卫生—中药学]