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作 者:张姮婕
机构地区:[1]成都市食品药品检验研究院,四川成都610045
出 处:《广州化工》2016年第21期127-129,共3页GuangZhou Chemical Industry
摘 要:采用高效液相色谱法测定利可君片中主药的含量。采用Agilent Eclipse Plus C18色谱柱(4.6×250 mm,5μm),流动相为磷酸二氢钾缓冲液(称取磷酸二氢钾1.36 g,加水溶解并稀释至1000 m L,用磷酸调节p H值至3.0)-乙腈(60∶40),柱温35℃,流速1.0 m L·min-1,检测波长210 nm,进样量20μL。利可君在10.01~250.2μg·m L-1浓度范围内有良好的线性关系(相关系数r=1),平均回收率为100.45%。利可君溶液在室温下不稳定,应临用新制。所建方法专属性好、准确、快捷,适用于利可君片的含量测定。To establish an HPLC method for content determination of Leucogen tablets, the Agilent Eclipse Plus C18 column (4.6 m×250 mm, 5μm) was adopted. The mobile phase consisted of phosphate buffer ( containing 1.36 g of Potassium Dihydrogen Phosphate in 1 litre of water, adjusted to pH 3.0 with phosphoric acid)-acetonitrile (60 : 40). The column temperature was kept at 35℃. The flow rate was 1.0 mL · min-1. The detection wavelength was set at 210 nm. The sample volume was 20 μL. The linear range of Leucogen was 10. 01 - 250. 2 μg· mL-l ( r = 1 ). The average recoveries were 100. 45%. The solution of Leueogen was not stable at room temperature, so should he used as soon as possible. The method of content determination of Leucogen tablets is specific, accurate and simple for content determination of Leucogen tablets.
分 类 号:R917[医药卫生—药物分析学]
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