曲尼司特治疗深Ⅱ度烧伤患者瘢痕增生的效果观察  

Efficacy of tranilast on treatment of hypertrophic scar caused by deep second-degree burn

作　　者：孟祥海[1] 孙超峰[1] 王晓琳[1] 李学拥[1] 

机构地区：[1]第四军医大学唐都医院烧伤整形科,西安710038

出　　处：《西南国防医药》2016年第11期1268-1271,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨口服曲尼司特治疗深Ⅱ度烧伤患者瘢痕形成的疗效及安全性。方法选择我院收治的60例深Ⅱ度烧伤致瘢痕形成患者作为研究对象,随机分为A、B组各30例。A组对瘢痕部位使用硅酮凝胶喷雾,B组在A组基础上加用曲尼司特口服。观察比较两组治疗效果、瘢痕以及不良反应情况。结果 A组总有效率(73.33%)远小于B组(90.00%)(P<0.05)。治疗后两组症状均有所缓解,但B组较A组各方面改善更为显著(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论口服曲尼司特治疗深Ⅱ度烧伤患者瘢痕形成具有良好的效果,安全性高,值得临床推广使用。Objective To explore the efficacy and safety of oral tranilast on the treatment of hypertrophic scar caused by deep second-degree burn. Methods A total of 60 patients with hypertrophic scar caused by deep second-degree burn admitted to our hospital were selected and randomly divided into groups A and B（n=30, respectively）. Silicone gel spray was applied to the scar sites in group A, while group B was treated with oral tranilast on this basis. The efficacy, scar and adverse reactions in the two groups were observed and compared. Results The ORR in group A（73.33%） was much lower than that in group B（90.00%）（P〈0.05）. The symptoms in the two groups after the treatment were relieved, and the improvement in group B was more significant than that in group A（P〈0.05）. The incidence of adverse reactions in the two groups had no significant difference（ P〉0.05）. Conclusion Oral tranilast has good effects on the treatment of hypertrophic scar caused by deep second-degree burn, and is highly safe and worthy of clinical popularization.

关 键 词：曲尼司特 深Ⅱ度烧伤 瘢痕形成 

分 类 号：R644[医药卫生—外科学]