葛根素抑制大鼠结肠平滑肌收缩活动的机制探讨  

Mechanism of inhibitory effect of puerarin on isolated colon smooth muscle of rats

作　　者：刁汇玲[1] 孙晖[1] 郭莉[1] 马中女[1] 

机构地区：[1]滨州医学院基础医学院生理教研室,烟台264003

出　　处：《滨州医学院学报》2016年第5期324-326,共3页Journal of Binzhou Medical University

基　　金：山东省高等学校科技计划(J13LL71)

摘　　要：目的探讨葛根素抑制大鼠离体结肠平滑肌收缩活动的作用机制。方法制备大鼠离体结肠平滑肌标本,用PowerLab数据采集分析系统记录结肠平滑肌收缩活动的变化。结果葛根素对大鼠离体结肠平滑肌的收缩活动具有明显抑制作用(P<0.05);阿托品、尼莫地平、普萘洛尔和格列本脲对结肠平滑肌收缩活动无明显作用(P>0.05),但可部分阻断葛根素对平滑肌收缩的抑制作用(P<0.05)。结论葛根素对大鼠离体结肠平滑肌收缩活动的抑制作用可能由β受体、M受体、K+通道和Ca2+通道所介导。Objective To explore the mechanisms of supressing the contractile activity of isolated colon smooth muscle of rats with Puerarin .Methods Powerlab signal processing instrument was used to observe the activity of isolated colon smooth mus‐cle of rats .Results Puerarin significantly exerted depressant effect on the contractile activity of the colon smooth muscle of rats .Atropine ,nimodipine ,propranolol and glibenclamide partially blocked the depressant action of puerarin .Conclusion Pu‐erarin inhibited the motility of the colon smooth muscle of rats ,which was partially mediated via adrenergic βreceptor ,cholin‐ergic M receptor ,potassium channel and calcium channel .

关 键 词：葛根素 离体结肠平滑肌 Β受体 M受体 K+通道 CA2+通道 

分 类 号：R286.11[医药卫生—中药学]