烯烃和2-溴-1,3-二羰基化合物光氧化还原法合成多取代二氢呋喃  

De novo synthesis of polysubstituted dihydrofurans using photoredox neutral coupling of alkenes with 2-bromo-1,3-dicarbonyl compounds

作　　者：俞寿云[1] 程远征[1] 

机构地区：[1]南京大学化学化工学院,南京210093

出　　处：《中国科技论文》2016年第18期2047-2049,2068,共4页China Sciencepaper

基　　金：高等学校博士学科点专项科研基金资助项目(20110091120008)

摘　　要：多取代二氢呋喃和呋喃的合成成为近几十年来的研究热点,但是这些合成方法通常需要当量的氧化剂或者苛刻的反应条件(较高的反应温度等)。所以,一种更加有效、绿色的合成二氢呋喃的方法仍旧需要去探究。本文报道了1种温和的、操作性强、环境友好的合成二氢呋喃的方法。这种方法采用可见光促进的光氧化还原中性的方式来完成,对多种溴化物和烯烃都能以很高的收率得到产物,而且避免了当量氧化剂的使用。Exploration on various synthetic protocols for polysubstituted dihydrofurans has been intense research interests for decades. However, stoichiometric oxidants or high temperature （normally over 80 ℃） are necessary in these reactions. Apparently, efficient methods in catalytic model without external stoichiometric oxidants to construct dihydrofurans at room temperature are still highly demanded. A conceptually new strategy has been described for mild, practical and environmentally friendly prepara- tion of polysubstituted dihydrofurans using visible light photoredox catalysis. These reactions between electron-deficient bromides and commercially available alkenes can be carried out at room temperature in good to excellent chemical yields without any external stoichiometric oxidants.

关 键 词：可见光 二氢呋喃 光氧化还原 

分 类 号：O626.11[理学—有机化学]