精原干细胞:生殖保护与再生医学的新来源  

Spermatogonial stem cells:new source of fertility preservation and reproductive medicine

作　　者：宁亮[1] 张倩倩[1] 杨林[1] 吴大鹏[1] 贺大林[1] 

机构地区：[1]西安交通大学第一附属医院泌尿外科,西安710061

出　　处：《中华细胞与干细胞杂志（电子版）》2016年第4期258-262,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金青年基金项目(B1300551)

摘　　要：精原干细胞(SSC)是存在于睾丸生精小管,不断增殖和分化以产生精子的男性生殖干细胞。SSC的冻存和移植被认为是未成年肿瘤患儿生殖保护的重要手段。近年来研究报道表明人类和鼠类的SSC可以在体内和体外分化为具有多能性的细胞,这些在表现型和功能上都和胚胎干细胞有一定的相似性。因此,精原干细胞SSC也被认为是很有希望成为再生医学中基于干细胞治疗方面的新来源。Banking and transplantation of SSCs may become a promising method to preserve the fertility of prepubertal patients. According to recent discoveries, the potential of spermatogonial stem cells to de-differentiate into pluripotent cells or transdifferentiate into other cell types is possible and thus spermatogonial stem cell banking is useful. Several researchers have reported the derivation of multipotent cells from both mouse and human spermatogonial stem cells. These spermatogonia-derived stem cells show similarities with embryonic stem cells both for phenotype and functionality, indicating that these cells may be a promising alternative source for stem cell-based therapies in regenerative medicine.

关 键 词：再生医学 精原细胞 干细胞移植 细胞分化 

分 类 号：R698[医药卫生—泌尿科学]