血清胱抑素C浓度与颈动脉粥样硬化的关系  

Association between serum concentration of cystatin C and carotid atherosclerosis

作　　者：梁登攀[1] 周鹏[1] 王秋林[1] 蔡国才[1] 李璐[1] 蒋利成[1] 李文章[1] 杨震[1] 蒲静[1] 

机构地区：[1]成都医学院第一附属医院心内科,成都610500

出　　处：《岭南心血管病杂志》2016年第5期563-565,572,共4页South China Journal of Cardiovascular Diseases

基　　金：成都医学院课题项目(项目编号:CYZ11-020)

摘　　要：目的 探讨血清胱抑素C（cystatin C）浓度与颈动脉粥样硬化的关系。方法 选择2012年1月至2014年1月在成都医学院第一附属医院心内科住院的患者1 263例,检测其血清胱抑素C、血脂、血糖等血液生化指标,彩色多普勒超声评价颈动脉内膜中层厚度（inteima-media thickness,IMT）及粥样硬化斑块的情况。根据彩色多普勒超声结果 将研究人群分为颈动脉粥样硬化组（IMT≥0.9 mm,伴或不伴有斑块形成）及颈动脉内膜正常组,用t检验分析两组患者血清胱抑素C、血脂、血糖等指标的差异。Spearman相关分析、Logistic回归分析血清胱抑素C与颈动脉粥样硬化的关系。结果 1 263例患者的年龄为（65.2±8.5）岁,男性共439例（34.8%）。颈动脉粥样硬化患者的血清胱抑素C浓度高于颈动脉内膜正常组,差异有统计学意义[（1.16±0.16）mg/L vs.（0.96±0.41）mg/L,P〈0.001]。相关分析结果 显示,血清胱抑素C与颈动脉粥样硬化呈正相关（r=0.293,P〈0.001）。多因素Logistic回归分析校正性别、年龄等因素后,血清胱抑素C与颈动脉粥样硬化独立相关（OR=2.682,95%CI：1.682-4.277,P〈0.001）。结论 血清胱抑素C浓度与颈动脉粥样硬化相关,血清胱抑素C可能是颈动脉粥样硬化的独立危险因素之一。Objectives To evaluate the association between serum concentration of cystatin C and carotid atherosclerosis. Methods From January 2012 to January 2014,1 263 patients from The First Affiliated Hospital of Chengdu Medical College were enrolled in this study. Medical data,including physical examinations,serum concentrations of cystatin C,lipid and lipoprotein,blood glucose and other biochemical markers and Duplex ultrasonographic scanning for the carotid artery were collected. Based on the results of carotid duplex uhrasonography, all the patients were assigned to two groups： patients with thickened intima-media and （or） atherosclerotic plaque were in group A, and the other patients with non-thickened intima-media and non-atherosclerotic plaque were in group B. Differences in serum concentrations of cystatin C, lipid and lipoprotein, blood glucose and other biochemical markers between the two groups were analyzed by using Student＇s t test. Correlation between clinic markers and carotid atherosclerosis was analyzed by using Spearman correlation analysis. Correlated factors of the carotid atherosclerosis were analyzed by using unconditional Logistic regression analysis. Results Serum concentration of cystatin C was significantly increased in group A than in group [（1.16±0.16） mg/L vs. （0.96±0.41） mg/L, P〈0.001）. Carotid atherosclerosis was positively correlated with serum concentration of cystatin C （r=0.293 ,P〈0.001 ）. Multivariate Logistic regression analysis adjustment for age, gender, diabetes mellitus, hypertension, serum lipid, lipoprotein and creatinine, high serum concentration of cystatin C was still an independent risk factor of carotid atherosclerosis（OR=2.682, 95%CI： 1.682-4.277, P〈0.001 ）. Conclusions Our data indicate that there is an association between serum concentration of cystatin C and carotid atherosclerosis. Cystatin C may be an independent risk factor of carotid atherosclerosis.

关 键 词：颈动脉粥样硬化 胱抑素C 彩色多普勒超声 

分 类 号：R543.4[医药卫生—心血管疾病]