新鲜洋葱汁对帕罗西汀所致雄性大鼠性功能障碍的影响及其机制研究  

Study on the effect of fresh onion juice on copulatory behavior in male rats with paroxetine-induced sexual dysfunction and its mechanism

作　　者：徐桃桃[1] 王熙[2] 张莹莹[1] 王丽[1] 陈雄[2] 

机构地区：[1]湖北医药学院附属人民医院,湖北十堰442000 [2]湖北省十堰市太和医院(湖北医药学院附属医院),湖北十堰442000

出　　处：《现代中西医结合杂志》2016年第33期3652-3654,3658,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：湖北省卫生和计划生育委员会中医药中西医结合科研项目(2013Z-Y39)

摘　　要：目的探讨新鲜洋葱汁对正常雄性大鼠和帕罗西汀所致性功能障碍雄性大鼠性功能和血清睾酮水平的影响,为后期临床研究提供实验依据。方法将有性行为能力的70只雄性大鼠随机分为7组,每组10只。对照组给予蒸馏水灌胃,0.5 m L洋葱汁组、1.0 m L洋葱汁组血清睾酮水平2.0 m L洋葱汁组分别给予相应剂量的新鲜洋葱汁灌胃,帕罗西汀组给予帕罗西汀悬浮液10 mg/kg灌胃,帕罗西汀加1.0 m L洋葱汁组、帕罗西汀加2.0 m L洋葱汁组分别给予帕罗西汀悬浮液10 mg/kg和相应剂量的新鲜洋葱汁灌胃,均1次/d,连续灌胃20 d。在末次灌胃结束后3 h,记录各组大鼠性行为参数及血清睾酮水平。结果 1.0 m L洋葱汁组和2.0 m L洋葱汁组大鼠的骑跨潜伏期、骑跨次数均明显低于对照组和0.5 m L洋葱汁组(P均<0.05),交配有效率和血清睾酮水平均明显高于对照组和0.5 m L洋葱汁组(P均<0.05);1.0 m L洋葱汁组和2.0 m L洋葱汁组大鼠的插入潜伏期和1.0 m L洋葱汁组大鼠的射精潜伏期均明显低于对照组(P均<0.05);1.0m L洋葱汁组大鼠的插入潜伏期和射精潜伏期均明显低于0.5m L洋葱汁组(P均<0.05)。帕罗西汀组大鼠的射精潜伏期明显长于对照组(P<0.05),血清睾酮水平明显低于对照组(P<0.05);帕罗西汀加1.0 m L洋葱汁组、帕罗西汀加2.0 m L洋葱汁组大鼠的骑跨潜伏期和帕罗西汀加2.0 m L洋葱汁组大鼠的骑跨次数均明显少于对照组和帕罗西汀组(P均<0.05);帕罗西汀加1.0 m L洋葱汁组、帕罗西汀加2.0 m L洋葱汁组大鼠的射精潜伏期均明显低于帕罗西汀组(P均<0.05),血清睾酮水平均明显高于帕罗西汀组(P均<0.05)。结论新鲜洋葱汁可以明显增强雄性大鼠的性功能,并可以通过提高血清睾酮水平来缓解帕罗西汀引起的性功能障碍,增强性交配行为。Objective It is to investigate the effects of onion juice on copulatory behavior and serum testosterone of sexually potent male rats and in male rats with paroxetine-induced sexual dysfunction,and provide experimental basis for clinical research in the later period. Methods 70 cases of male rats with normal sexual capacity were divided into seven groups,10 cases in each group. The animals were treated with distilled water gavage in the control group,and with 0. 5,1. 0 and 2. 0 m L onion juice gavage in the corresponding dose onion juice groups,with 10 mg / kg paroxetine in the paroxetine group,with 10 mg / kg paroxetine plus 1. 0,2. 0 m L onion juice in the corresponding dose groups,once a day,continuous treated for 20 days. At the end of the treatments,sexual behavior parameters and testosterone levels were measured and compared among all the groups.Results The incubation period and the times of riding in the 1. 0,2. 0 m L onion juice group were significantly lower than those in the control group and the 0. 5 m L onion juice group（ all P 0. 05）,the efficiency of mating and serum testosterone levels were significantly higher than those in the control group and the 0. 5 m L onion juice group（ all P 0. 05）; the incubation period of insertion in the 1. 0,2. 0 m L onion juice group and the incubation period of ejaculation in the 1. 0 m L onion juice group were significantly lower than those in the control group（ all P 0. 05）; the incubation period of insertion and ejaculation in the1. 0 m L onion juice group were significantly lower than those in the 0. 5 m L onion juice group（ all P 0. 05）. The incubation period of ejaculation in the paroxetine group was significantly longer than the control group（ P 0. 05）,the level of serum testosterone was significantly lower than that in the control group（ P 0. 05）. The incubation period of riding in the paroxetineplus 1. 0 mL onion juice group and the times of riding in the paroxetine plus 2. 0 mL onion juice group were significantly less than those in t

关 键 词：洋葱 帕罗西汀 性行为 睾酮 

分 类 号：R332[医药卫生—人体生理学]