胃癌患者外周血IL-26的水平及其诊断价值  

Expression of serum IL-26 and its diagnostic value in patients with gastric cancer

作　　者：许彬彬[1] 陈志红[2] 汪超[1] 魏法星[3] 

机构地区：[1]江苏大学医学院,江苏镇江212013 [2]江苏大学附属人民医院胃肠外科,江苏镇江212002 [3]江苏大学附属医院急诊科,江苏镇江212003

出　　处：《江苏大学学报（医学版）》2016年第5期429-432,共4页Journal of Jiangsu University：Medicine Edition

基　　金：镇江市社会发展基金资助项目(SH20130039)

摘　　要：目的：探讨胃癌患者血清白介素26（IL-26）的表达及临床价值。方法：收集176例胃癌患者（胃癌组）和同期176例健康体检者（对照组），ELISA法检测两组受试者血清IL-26的表达及血清肿瘤标记物癌胚抗原、糖类抗原199（CA199）、糖类抗原242（CA242）、糖类抗原724（CA724）的表达，并分析差异；应用ROC分析IL-26临床应用诊断价值，并与血清肿瘤标记物作比较。结果：胃癌组血清IL-26表达明显高于对照组（Z＝2．3656，P＝0．018）。IL-26曲线下面积为0．956，95％CI为0．909～0．958，诊断敏感度为79．2％，诊断特异性为87．4％（P＝0．007）；IL-26诊断敏感度和特异性均高于血清肿瘤标记物。结论：血清IL-26在胃癌患者血清中呈高表达，其能提高胃癌的诊断效能。Objective：To explore the expression of serum IL-26 in patient with gastric cancer and its diagnostic value.Methods：A total of 1 76 patients with gastric cancer（cancer group）and 1 76 healthy person（control group）were enrolled in the study.Levels of serum IL-26 and carcinoembryonic antigen （CEA）,CA1 99,CA242,CA724 in two groups were determined by ELISA.ROC statistical diagnostic test were used to explore the clinical diagnostic value of IL-26 and compared with serum tumor markers. Results：The expression level of IL-26 in gastric cancer group was significantly higher than that in control group（P〈0.05）.The area under the ROC curve of IL-26 was 0.956,the 95%confidence interval was 0.909-0.958.The diagnostic sensitivity was 79.2%,the diagnostic specificity was 87.4%（P =0.007）;the diagnostic sensitivity and specificity of IL-26 was higher than CEA,CA1 99,CA242, CA724.Conclusion：Patients with gastric cancer showed high levels of serum IL-26,which could be used to improve the diagnostic efficacy of gastric cancer.

关 键 词：胃癌 白介素26 诊断价值 

分 类 号：R446.11[医药卫生—诊断学]