加味天雄散对弱精子症患者精浆氧化损伤的保护作用  

Protective Effect of Jiawei Tianxiong Powder on Seminal Plasma Injury Induced by Oxidative Damage in Patients with Asthenospermia

作　　者：耿强[1] 郭军[2] 欧阳斌[1] 王福[2] 韩强[3] 赵玉[1] 高庆和[2] 李重[1] 余国今[2] 

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]中国中医科学院西苑医院,北京100091 [3]首都医科大学附属北京中医医院,北京100010

出　　处：《山东中医杂志》2016年第10期878-880,共3页Shandong Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(编号:81202695);中国中医科学院优势病种资助项目(编号:CACMS08Y0025)

摘　　要：目的 :观察加味天雄散对弱精子症患者精浆氧化损伤的影响并探讨其机制。方法 :本组120例随机分为对照组、加味天雄散全方组、补肾组和健脾组,每组30例,并设立精液分析正常的健康志愿者30例。4组分别治疗3个月后检测精液质量和精浆超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果:治疗后全方组A级精子和A+B级精子百分率改善更明显(P<0.01),与健康志愿者相比,弱精子症患者精浆SOD活力明显降低,精浆MDA水平明显下降,治疗后全方组患者精浆SOD活力提高更为明显,精浆MDA水平降低更为明显,差异有统计学意义。结论:加味天雄散能够提高精浆组织的抗氧化水平,降低精浆MDA水平,提高精子的活力。Objective ：To observe the effect and mechanism of Jiawei Tianxiong powder on seminal plasma in- jury induced by oxidative damage in patients with asthenospermia. Methods：There were 120 patients random- ly divided into 4 groups：control group,Jiawei Tianxiong powder group,tonifying kidney group,tonifying spleen group,30 cases in each group. Besides there were 30 healthy volunteers with normal semen. Three months after treatment,semen quality and seminal plasma SOD and MDA levels were examined. Results：After the treatment,the percentage of grade A and grade A＋B sperm were improved obviously in the Jiawei Tianxiong group（P〈0.01）. Compared with the healthy volunteers,patients with asthnospermla showed obviously low seminal plasma SOD level and high seminal level was increased and seminal plasma MDA clusion：Jiawei Tianxing powder can improve plasma MDA level. Therefore it could enhance plasma MDA level. After the treatment,seminal plasma SOD level was decreased with significant statistical difference. Con- the antioxidant ability in seminal plasma,and reduce seminal the sperm vitality.

关 键 词：加味天雄散 弱精子症 精浆 氧化损伤 

分 类 号：R256.56[医药卫生—中医内科学]