八宝丹胶囊联合鸦胆子油乳介入治疗湿热聚毒型原发性肝癌的临床研究  

Clinical efficacy of Babaodan capsules combined with interventional therapy with Brucea javanica oil emulsion in treatment of damp-heat accumulation type primary liver cancer

作　　者：叶书林[1] 曾普华[2] 郜文辉[1] 潘敏求[2] 蒋益兰[2] 蔡美[2] 邓湘生[2] 付亚丽[1] 张湘荣[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]中国中医科学院全国中医药传承博士后流动站,湖南省中医药研究院附属医院,湖南省中医肿瘤诊疗中心,湖南长沙410006

出　　处：《湖南中医杂志》2016年第10期1-4,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局首届中医药传承博士后合作项目(2015);湖南省“225”卫生人才工程项目(2013)

摘　　要：目的:评价八宝丹胶囊联合鸦胆子油乳经血管介入治疗湿热聚毒型原发性肝癌的临床疗效。方法:将53例确诊为原发性肝癌且辨证符合湿热聚毒证的患者随机分为八宝丹胶囊联合鸦胆子油乳介入组(治疗组)和单纯鸦胆子油乳介入组(对照组),比较两组在瘤体、肝功能、甲胎蛋白、中医临床证候积分、生活质量、毒副反应等方面的变化。结果:治疗组疾病控制率(85.2%)高于对照组(80.8%),但差异无统计学意义(P>0.05);治疗组治疗后ALT、AST、TBiL及AFP的改善均有统计学意义(P<0.05),其中ALT、AFP的改善优于对照组(P<0.05);治疗后中医临床证候积分差值,治疗组和对照组分别为(14.5±0.6)分和(11.3±0.4)分,差异有统计学意义(P<0.01);KPS功能状态有效率治疗组为96.3%,对照组为84.6%,差异有统计学意义(P<0.05);治疗组治疗后在心理功能、症状/副作用、总生活质量等方面评分均较治疗前有所提高(P<0.05),且优于对照组(P<0.05);治疗组腹痛、发热、恶心呕吐、肝毒性、骨髓抑制等毒副反应发生率均低于对照组,差异有统计学意义(P<0.05)。结论:八宝丹胶囊联合鸦胆子油乳介入治疗湿热聚毒型原发性肝癌,较单纯使用鸦胆子油乳在改善肝功能、提高生活质量、减轻术后毒副反应等方面均有优势,值得推广应用。Objective： To evaluate the clinical efficacy of Babaodan capsules combined with vascular interventional therapy with Brucea javanica oil emulsion in the treatment of damp- heat accumulation type primary liver cancer. Methods： A total of 53 patients who were diagnosed with damp- heat accumulation type primary liver cancer were randomly divided into treatment group and control group. The treatment group received Babaodan capsules combined with vascular interventional therapy with Brucea javanica oil emulsion,while the control group received vascular interventional therapy with Brucea javanica oil emulsion alone. The following indices were compared between the two groups： tumor body,serum levels of alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBil）,and alpha- fetoprotein（ AFP）,traditional Chinese medicine（ TCM） syndrome score,quality of life（ Karnofsky Performance Scale,KPS）,and incidence of toxic and side effects. Results： After treatment,there was no significant difference in disease control rate between the treatment group and the control group（ 85. 2% vs 80. 8%,P〉0. 05）. The treatment group showed significant improvements in serum levels of ALT,AST,TBil,and AFP（ P〈0. 05）,and the treatment group had significantly more improvements in serum levels of ALT and AFP than the control group（ P〈0. 05）. There were significant differences in the change in TCM syndrome score（ 14. 5 ± 0. 6 vs 11. 3 ± 0. 4,P〈0. 01）and improvement rate of KPS score（ 96. 3% vs 84. 6%,P〈0. 05） between the treatment group and the control group. The treatment group showed significant improvements in psychological function,symptoms / side effects,and overall quality of life（ P〈0. 05） and had significantly better outcomes in these aspects than the control group（ P〈0. 05）. The treatment group had significantly lower incidence rates of abdominal pain,fever,nausea and vomiting,hepatotoxicity,and myelosuppression than the control group（ P〈

关 键 词：原发性肝癌 中医药疗法 八宝丹胶囊 鸦胆子油乳 血管介入 

分 类 号：R273.57[医药卫生—中西医结合]