Toll样受体9的功能及其致病机制  

Functions of toll-like receptor 9 and underlying mechanism

作　　者：鲍文朵娜 施少林[1] 

机构地区：[1]南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2016年第5期456-460,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金(81370827);江苏省自然科学基金(BK20131324)

摘　　要：Toll样受体9(TLR9)是Toll样模式识别受体家族成员之一,表达于免疫细胞,通过与细菌DNA作用而诱导机体的固有免疫反应。近年来的研究发现,TLR9也表达于其他几种非免疫细胞,包括肾小球足细胞,并以线粒体DNA为配体,激活细胞的损伤信号通路,从而参与细胞损伤。本文就TLR9在免疫和非免疫细胞中的作用及其机制作一综述。Toll-like Receptor 9 （TLR9） is a member of Toll-like receptor family that use pathogen associated molecule patterns （PAMPs） as ligands. It is expressed in immune cells and senses bacterial DNA ligand to induce innate immune response. Recent studies have shown that TLR9 is also expressed in several non-immune cells,including glomerular podocyte, and uses mitochondrial DNA as ligand to activate signaling pathways that lead to cell injury. Here, we will review the roles of TLR9 in immune cells and non-immune cells and the underlying mechanisms.

关 键 词：TOLL样受体9 固有免疫 线粒体DNA 足细胞 

分 类 号：R392[医药卫生—免疫学]