移植肾BK病毒肾病发病机制及治疗  

Mechanisms of BK virus infection in renal transplant and therapeutic implication

作　　者：谢轲楠[1] 陈劲松[2] 

机构地区：[1]南京大学医学院附属金陵医院(南京军区南京总医院)肾脏科,博士研究生南京210016 [2]南京大学医学院附属金陵医院(南京军区南京总医院)国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2016年第5期484-488,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：BK病毒(BKV)可导致移植肾BKV相关性肾病,造成移植物的丢失。BKV潜伏在泌尿道中,可能通过移植由供肾传染给受者,并在受者体内激活,在肾小管上皮细胞的细胞核内复制。子代BKV逸出并感染其他肾小管上皮细胞,造成病毒播散。BKV感染的机制和动力学还有待阐明。BKV感染的治疗主要有两个途径:一是减少免疫抑制剂,其弊端是易引发排斥反应;二是使用抗病毒药物,但疗效尚有争议。了解早期病毒感染方式,有助于研发有效的抗病毒药物。本文着力于阐述BKV对人体靶细胞的入侵和细胞间传播途径,并基于BKV感染肾脏细胞的机制,探讨可能有效的治疗方法。BK virus （BKV） can cause BKV nephritis in renal transplant patients and has become a significant reason for graft loss. BKV is latent in the urogenital tract, and most likely is transported from the donor kidney to recipent. BKV reactivates in recipents, virus DNA replicates in the nucleus of renal epithelial tubular cells, and daughter viruses are released and enter other renal epithelial cells to spread infection. A lot of factors about the mechanism and kinetics of BKV infection remain unclear. There are mainly two ways of treating BKV infection, one is to reduce immunosuppressive agents, but this may increase the risk of rejection; the other is to use anti-viral drugs, but these therapies have inconsistent results. This review will describe the BKV entry in target human ceils, intracellular trafficking pathways of BKV particles and potential therapeutic implications based on understanding of mechanisms of BKV.

关 键 词：BK病毒 他汀 细胞受体 肾移植 

分 类 号：R699.2[医药卫生—泌尿科学]