硫酸软骨素的研究进展及其应用前景  

Chondroitin Sulfate with Potential Pharmacological Activities: Research Progress and Its Application Prospect

作　　者：周跃钢[1] 

机构地区：[1]重庆理工大学药学与生物工程学院,重庆400054

出　　处：《中国药学杂志》2016年第21期1821-1825,共5页Chinese Pharmaceutical Journal

基　　金：国家留学基金委访问学者奖学金资助项目(2006102368);日本科学与技术国际交流协会资助项目(2007)部分资助

摘　　要：硫酸软骨素(CS)是由重复二糖单位组成的结构多样化的阴离子多糖链,具有多种药理活性。在查阅CS研究的最新文献基础上,综述了CS在骨关节炎治疗、抗癌转移、促神经细胞生长、促进伤口愈合、抗病毒、骨生成领域中的药理以及相关应用领域的研究进展,讨论了目前研究和应用中存在的问题,以及应用化学酶学途径规模化合成结构专一的硫酸软骨素,用于骨关节炎治疗、癌转移预防与治疗等的可能性。Chondroitin sulfate （CS） is a heterogeneous and negatively charged polysaccharide composed of repeating disaccharide- units, and has many pharmacological activities. CS has been recommended as symptomatic slow acting drugs for osteoarthritis （SYSADOA） in clinical practice. CS is shown to have promising prospect as a potential candidate for anti-metastasis of cancers and as a neurite outgrowth agent for neurodegenerative diseases such as Alzheimer＇s disease and Parkinson＇s disease characterized by progres- sive loss of neurons. Moreover, CS is also involved in interaction with virus during its cell entry, wound healing and osteogenesis, and may be a promising drug candidate in these areas. Based on original publications, the research advances of CS in these areas and its applications were reviewed. The possibility of chemoenzymatic synthesis of specific CS chains as potential drugs was also discussed here, which may be used in the treatment of osteoarthritis, anti-metastasis of cancers, and so on.

关 键 词：硫酸软骨素 骨关节炎 抗癌转移 促神经细胞生长 神经变性疾病 生物技术 

分 类 号：R963[医药卫生—微生物与生化药学]