微囊泡及分泌型microRNAs与冠状动脉粥样硬化性疾病的关系研究进展  

Research updates of microvesicles and secreted microRNAs in coronary atherosclerotic diseases

作　　者：万淑君[1] 王成[1] 汪俊军[1] 

机构地区：[1]南京军区南京总医院解放军检验医学研究所,南京医学硕士研究生210002

出　　处：《医学研究生学报》2016年第11期1214-1219,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81271904);江苏省自然科学基金(BK20140730)

摘　　要：微囊泡（microvesicles,MVS） 是细胞分泌的一类直径约为30-1000 mn的膜性囊泡结构,内含脂类、蛋白质及核酸等多种生物分子,在冠状动脉粥样硬化性疾病（ coronary atherosclerosis disease,CAD）及其细胞间信息交流中发挥重要作用.MV中包裹大量微小核糖核酸（microRNAs,miRNAS） ,称为分泌型miRNAs.分泌型miRNAs具有多种生理功能,其可作为CAD 的潜在生物标志物.另外imRNAs可被M V s运输至靶细胞,调节细胞基因表达,与C A D 的发生、发展密切相关.文中就微囊泡及其分泌imRNAs与CAD发生、发展的关系进行综述.Microvesicles( MVs) are membranous vesicles( 30-1000 nm in diameter) secreted from almost cells. They contain various biological molecules such as lipids,proteins,mRNAs and microRNAs( miRNAs),which play an important role in the development of coronary atherosclerosis disease( CAD) and communication among different cells. miRNAs within MVs are called secreted miRNAs,which can be transported to target cells by MVs and regulate gene expressions through post-transcriptional level. miRNAs are closely related to pathological process of coronary atherosclerosis disease and might be the potential biomarkers for CAD. This paper presents the relationship between MVs containing miRNAs and coronary atherosclerosis disease.

关 键 词：微囊泡 分泌型microRNAs 炎症反应 动脉粥样硬化 冠状动脉粥样硬化性疾病 

分 类 号：R541.4[医药卫生—心血管疾病]