乌蔹莓膏治疗高位复杂性肛瘘术后创面的临床观察  

Clinical Observation of Cayratia japonica Cream in the Treatment of Wound after High Complex Anal Fistula Surgery

作　　者：郑雪平[1] 王业皇[1] 樊志敏[1] 戴功建[1] 徐俊华[1] 韩宁[1] 

机构地区：[1]南京中医药大学附属第三医院肛肠科,南京210001

出　　处：《中国药房》2016年第32期4534-4536,共3页China Pharmacy

基　　金：南京市科技发展计划项目(No.201503033)

摘　　要：目的:观察乌蔹莓膏治疗高位复杂性肛瘘术后创面的临床疗效及安全性。方法:选取拟行高位复杂性肛瘘患者72例,按随机数字表法分为对照组和观察组,各36例。两组患者均行高位复杂性肛瘘术。对照组患者术后清洗创面,给予凡士林油纱条外敷创面,每天1次;观察组患者术后清洗创面,给予乌蔹莓膏外敷创面,再敷凡士林油纱条,每天1次。两组患者均用药至创面愈合为止。观察两组患者治疗后临床疗效、创面愈合时间、创面分泌物p H值、创面分泌物量(以浸透纱布总数计)和疼痛程度[采用视觉模拟(VAS)评分法]、创面二次感染发生率及不良反应发生情况。结果:观察组患者治疗后治愈率和创面分泌物p H值均显著高于对照组,创面愈合时间、创面分泌物浸透纱布总数、VAS评分和创面二次感染发生率均显著低于或短于对照组,差异均有统计学意义(P<0.05)。两者患者均未见明显不良反应发生。结论:乌蔹莓膏治疗高位复杂性肛瘘术后创面疗效较好,并能改善创面微环境,降低复发率,且安全性较好。OBJECTIVE： To observe clinical efficacy and safety of Cayratia japonica cream in the treatment of wound after high complex anal fistula surgery. METHODS： 72 patients with high complex anal fistula were selected and divided into control group and observation group according to random number table, with 36 cases in each group. Both groups received high complex anal fistula surgery. Control group was given vaseline gauze for wound dressing, once a day, after cleaning surgery wound; obser- vation group applied C. japonica cream and then was given vaseline gauze for wound dressing, once a day, after cleaning surgery wound. Both groups was given medicine utile wound healing. Clinical efficacy, healing time, pH value of wound secretion, the rate of pterygium, the amount of wound secretion （by total anout of saked gauze）, pain degree （by VAS score） the incidence of wound secondary infection and the occurrence of ADR were observed in 2 groups after treatment. RESULTS： The cure rate pH value of wound secretion（by total anout of saked gauze）, VAS score and in observation group after treatment were significantly lower or shorter than in control group, with statistical signignificance （P〈0.05）. There were no obvious adverse reactions in 2 groups. CONCLUSIONS： C. japonica cream can effectively reduce recurrence rate after high complex anal fistula surgery and improve wound microenvironment with good safety.

关 键 词：高位复杂性肛瘘:乌蔹莓膏 复发率 视觉模拟评分 

分 类 号：R266[医药卫生—中医外科学]