芪胶升白胶囊在心肌梗死伴高血压患者治疗中的作用  

Effect of Qijiao Shengbai Capsule in the Treatment of Myocardial Infarction Complicated with Hypertension

作　　者：郭长磊[1] 张少利[1] 尹宏磊[1] 张培勇[1] 吕风华[1] 

机构地区：[1]新乡医学院第一附属医院心血管外科,河南卫辉453100

出　　处：《中国药房》2016年第32期4570-4573,共4页China Pharmacy

摘　　要：目的:观察芪胶升白胶囊对心肌梗死伴高血压患者心脏功能、肾功能、外周血常规、细胞免疫指标的影响及安全性。方法:选择我院心肌梗死伴高血压患者58例,按住院号单双号顺序分为对照组和观察组,各29例。对照组患者均给予降压、调脂和预防心肌梗死的常规治疗,观察组患者在此基础上加用芪胶升白胶囊2.0 g,po,tid。两组患者疗程均为6个月。观察两组患者治疗前后心脏功能、肾功能、外周血常规、T细胞亚群指标水平和不良反应发生情况。结果:治疗前,两组患者以上指标比较,差异均无统计学意义(P>0.05)。治疗后,两组患者左室收缩末期内径(LVSd)、左室舒张末期内径(LVDd)、室间隔舒张期厚度(IVSDT)、左室后壁舒张期厚度(LVPWT)均明显降低,差异有统计学意义(P<0.05);但组间比较差异无统计学意义(P>0.05)。治疗后,观察组患者尿微量白蛋白(MAU)、尿酸(UA)以及对照组患者MAU均明显降低,观察组患者肾小球滤过率(eGFR)明显升高,差异均有统计学意义(P<0.05);且观察组患者以上指标改善程度均明显优于对照组,差异有统计学意义(P<0.05)。对照组患者外周血常规指标和T细胞亚群指标改变程度均大于观察组,差异均有统计学意义(P<0.05)。观察组患者未见明显不良反应发生。结论:芪胶升白胶囊不会影响心肌梗死伴高血压患者的心功能,对肾功能具有保护作用,可强化机体免疫功能,安全性较高。OBJECTIVE： To observe the effects and safety of Qijiao shengbai capsule on cardiac fimction, renal tunction, peripheral routine blood test and celluar immunity indexes of patients with myocardial infarction complicated with hypertension. METHODS： 58 patients with myocardial infarction complicated with hypertension in our hospital were selected and divided into control group and the observation group, with 29 cases in each group according to the even and odd number of hospitalization or- der. Control group was given symptomatic treatment as bringing down high blood pressure, regulating blood lipid and preventing myocardial infarction. On this basis, observation group was additionally treated with Qijiao shengbai capsule 2.0 g, po, tid. Treat- ment course of 2 groups lasted for 6 months. Cardiac function, renal function, peripheral routine blood test, Tcell subset and the oc- currence of ADR were observed in 2 groups before and after treatment. RESULTS： Before treatment, there were no statistical sig- nificance in above indexes between 2 groups （P-0.05）. After treatment, LVSd, LVDd, IVSDT and LVPWT of 2 groups were all decreased significantly, with statistical significance （P〈0.05） ; there was no statistical significance between 2 groups （P〉0.05）. MAU and UA of observation group and MAU of control group were decreased significantly after treatment; eGFR of observation group was increased significantly, with statistical significance （P〈0.05）. The improvement of above indexes in observation group were significantly better than in control group, with statistical significance （P〈0.05）. The change of peripheral routine blood index- es and T lymphocyte subset in obserration group were greater than in control group, with statistical signifrcance （P（0.05）. No obvious ADR was found in observation group. CONCLUSIONS： Qijiao shengbai capsule do not influence cardiac function of myocar- dial infarction patients with hypertension, can protect renal function and strengthen body immunity

关 键 词：心肌梗死伴高血压 芪胶升白胶囊 心脏功能 肾功能 T细胞亚群 

分 类 号：R542[医药卫生—心血管疾病]