乙肝免疫球蛋白在乙肝感染孕妇产前阻断中的作用  

Effects of the hepatitis B immune globulin on the antenatal interruption of pregnant women infected with hepatitis B virus

作　　者：李栋梁[1] 汤仁树[1] 刘振武[1] 刘旭祥[1] 王蓓[1] 王晓萍[1] 

机构地区：[1]合肥市疾病预防控制中心免疫规划科,安徽合肥230000

出　　处：《中华疾病控制杂志》2016年第9期885-887,892,共4页Chinese Journal of Disease Control & Prevention

基　　金：合肥市科技计划项目(2010082)

摘　　要：目的对合肥市乙肝感染孕妇母婴阻断结果进行分析,评价现行的产前阻断方式的有效性,为阻断乙肝病毒垂直传播提供依据。方法利用已经建立的合肥市乙肝感染孕妇监测系统,按照乙肝感染孕妇乙型肝炎病毒-DNA(hepatitis B virus-DNA,HBV-DNA)滴度的风险区和产前是否注射乙肝免疫球蛋白分组,在婴儿一周岁时检测乙肝五项,乙肝表面抗原(hepatitis B surface antigen,HBs Ag)阳性者为阻断失败。同时对注射乙肝免疫球蛋白(hepatitis B immune globulin,HBIg)的乙肝感染孕妇进行注射前和注射后HBV-DNA病毒滴度监测,以研究产前注射乙肝免疫球蛋白对乙肝病毒垂直传播的影响。结果 2009-2013年全市共监测乙肝感染孕妇395例,对照组的阳性率为2.74%,阻断组的阳性率为3.88%。x^2检验显示两组间阳性率差异无统计学意义。注射HBIg的乙肝感染孕妇注射前和注射后HBV-DNA病毒滴度变化差异无统计学意义。结论乙肝感染孕妇产前注射乙肝免疫球蛋白的效果有待进一步研究。Objective To analyze the results of the mother-to-infant transmission interrupting of hepatitis B virus （HBV） in Hefei and evaluate the validity of current antenatal interruption method, so as to provide reasonable basis for the interrupting. Methods This study was established on the monitoring system of the pregnant women infected with HBV in Hefei. The pregnant women infected with HBV were grouped according to the risk of HBV-DNA titers and condition of ante- natal injection of hepatitis B immune globulin （HBIg）. All their infants were investigated five makers of hepatitis B at one year old. And if the hepatitis B surface antigen （HBsAg） was positive, it came that the interrupting failed. The HBV-DNA titers of the pregnant women injected with HBIg were monitored both before and after injection, so as to study the effect of HBIg on the mother-to-infant transmission antenatal interruption. Results The total cases of pregnant women with HBV were 395 from 2009 to 2013. The positive rate of control group was 2. 74% and the treatment group was 3. 88%. The difference between two rates was not statistically significant by Chi-square test and also the titer change between before and after injection. Conclusions Effect of HBIg on the antenatal interruption of pregnant women infected with HBV should be further studied.

关 键 词：肝炎 孕妇 对比研究 

分 类 号：R512.62[医药卫生—内科学] R181.2[医药卫生—临床医学]