金昌队列单抗HB-s阳性人群肝功酶异常与脂质代谢指标相关性分析  

Study on the relationship between ALT,AST,GGT disorders and lipid metabolic parameters in Anti-HBs positive population of Jinchang cohort: a cross-sectional study

作　　者：姬晓虹 白亚娜[1] 王旭天 李娟生[1] 丁皎[2] 程宁[3] 胡晓斌[1] 刘燕青[1] 彭峥[1] 

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计学研究所,甘肃兰州730000 [2]金川集团股份有限公司职工医院检验科,甘肃金昌737103 [3]兰州大学基础医学院医学实验中心,甘肃兰州730000

出　　处：《中华疾病控制杂志》2016年第9期893-896,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家医改重大专项;国家重大公共卫生服务项目(财社[2012]64号);金川有色金属股份有限公司与兰州大学合作项目(金科综2012-13)

摘　　要：目的探讨金昌队列单抗-HBs阳性人群肝功酶异常与脂质代谢指标的关系。方法整群抽取2011年6月~2013年12月进入金昌队列且排除各种肝病史的单抗-HBs阳性者14 467例作为研究对象,通过实验室血清学检测相关酶学及脂质代谢指标。结果该人群丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、谷氨酰转肽酶(gamma-glutamyltransferase,GGT)异常检出率分别为21.35%、17.45%、15.01%,均为男性高于女性(均有P<0.001)。趋势性x^2检验分析显示,随着甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)、体质指数(body mass index,BMI)升高,ALT、AST、GGT异常检出率升高(均有P<0.001);随着高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)升高,ALT、AST、GGT异常检出率下降(均有P<0.001),具有剂量反应关系。尿酸(uric acid,UA)异常组ALT、AST、GGT异常检出率均高于正常组(均有P<0.001)。结论金昌队列单抗-HBs阳性人群ALT、AST、GGT异常检出率均为男性高于女性,且与BMI、TG、TC、LDL-C、HDL-C存在剂量反应关系。Objective To analyze the relationship between alanine aminotransferase （ALT）, aspartate amin- otransferase （ AST）, gamma-glutamyltransferase （GGT） disorders and lipid metabolic parameters in Anti-HBs positive pop- ulation of Jinchang cohort. Methods A Cross-sectional study was conducted, and a total of 14 467 Anti-HBs positive study subjects without any kinds of hepatitis history were selected from Jinchang cohort during June 2011 to December 2013 by cluster sampling. Lipid metabolic parameters and ALT, AST, GGT were detected by laboratory serology method. Re- suits The detection rates of ALT, AST, GGT disorders were 21.35%, 17. 45%, 15.01% respectively, and the detection rates for males was higher than that for females （ all P 〈 0. 001 ）. Along with triglyceride （ TG ）, total cholesterol （ TC）, low density lipoprotein cholesterol （LDL-C）, body mass index （BMI） increasing, there were higher detection rates of ALT, AST, GGT disorders（ all P 〈0. 001 ）. While with the high density lipoprotein cholesterol （HDL-C） increasing, the detec- tion rates of ALT, AST, GGT disorders was gradually decreased （ all P 〈0. 001 ）, showing a dose-response relationship. In addition, the detection rates of ALT, AST, GGT disorders of Uric acid （UA） abnormal group were higher than that of nor- mal group （ all P 〈 0. 001 ）. Conclusions The detection rates of ALT, AST, GGT disorders were high in Anti-HBs posi- tive population of Jinchang cohort, and male should be paid to the major prevention and control. Dose-response relationship was observed between detection rates of ALT, AST, GGT disorders and BMI, TG, TC, LDL-C, HDL-C.

关 键 词：天冬氨酸氨基转移酶类 横断面研究 流行病学方法 

分 类 号：R181.22[医药卫生—流行病学]