稳定期慢性阻塞性肺疾病患者非侵入性标记物研究  

Non-invasive markers in patients with stable chronic obstructive pulmonary disease

作　　者：鞠俊强[1] 朱正太 李华[1] 滕茂蓉[1] 

机构地区：[1]泰州市人民医院老年科,江苏泰州225300

出　　处：《临床荟萃》2016年第11期1213-1217,共5页Clinical Focus

基　　金：南京医科大学科技发展基金项目(2013NJMU136)

摘　　要：目的比较慢性阻塞性肺疾病(COPD)患者和健康受试者非侵入性标记物,评估其与吸烟的关系。方法选取在我院治疗的稳定期COPD戒烟患者52例(COPD EX组),稳定期COPD吸烟患者36例(COPD S组),在我院体检的健康的吸烟者23例(HE S组),健康的戒烟者23例(HE EX组)。比较所有受试者呼出气冷凝物(EBC)、痰液中前列腺素E2(PGE_2)和异构前列腺素15-F2t-isoprostane(15-F2t-IsoP)的水平、呼出气一氧化氮(FeNO)、痰细胞计数和肺功能。结果与COPD S组比较,COPD EX组的FeNO值明显提高;与两健康组比较,两COPD组EBC中15-F2t-IsoP水平明显升高(P<0.05);与同等健康状况的戒烟者比较,吸烟者尿液中15-F2t-IsoP水平升高(P<0.05)。结论不同类型炎症性标志物的联合检测分析可用于对COPD患者呼吸炎症的综合评估。Objective To compare the non-invasive markers between chronic obstructive pulmonary disease（COPD）patients and healthy subjects and to assess their relationship with smoking.Methods The subjects included52 COPD ex-smoking patients（COPD EX group,n =52）and 36 smoking patients（COPD S group,n =36）treated in our hospital,23 healthy ex-smokers（HE EX group,n =23）and 23 healthy smokers（HE S group,n =23）medically examined in our hospital.Prostaglandin E2（PGE2）,and prostaglandin isomers 15-F2t-isoprostane（15-F2t-IsoP）concentrations in sputum,exhaled breath condensate（EBC）,fraction of exhaled nitric oxide,sputum cell counts and pulmonary function test were detected and compared.Results Compared with COPD S group,FeNO values in COPD EX group increased significantly（P〈0.01）;Compared with healthy group,the EBC 15-F2t-IsoP concentrations in two groups with COPD increased significantly（P〈0.05）;Compared with smokers who had equal health status,the urine 15-F2t-IsoP concentration in both smokers groups increased significantly（P〈0.05）.Conclusion The combination of different types of inflammatory markers can be used for a comprehensive assessment of COPD respiratory inflammation.

关 键 词：肺疾病 慢性阻塞性 生物学标记 吸烟 

分 类 号：R563.9[医药卫生—呼吸系统]