2型糖尿病中血清GGT与血糖水平的相关性研究  

The correlation of serum GGT with glucose level in patients with type 2 diabetes

作　　者：孔曼[1] 罗振钊[1] 卢忠心[1] 曹小淬 张红梅[1] 

机构地区：[1]武汉市中心医院检验科,武汉430014

出　　处：《中国医师杂志》2016年第10期1511-1513,共3页Journal of Chinese Physician

摘　　要：目的探讨糖尿病患者血清γ-谷氨酰转移酶（GGT）水平与空腹血糖的关系，并评估体重指数（BMI）、年龄、性别、血脂等对该关系的影响。方法选取正常体检者120例、3次平均空腹血糖值6．0-7．0mg／dl的住院患者128例、3次平均空腹血糖值〉7．0mg／dl的住院患者124例，采用免疫比浊法测定血清中肝酶（GGT、AST、ALT、ALP）、血脂（TC、TG），采用酶法测定空腹血糖（GLU）的水平，采用高效液相色谱串联电喷雾电离一级质谱法测定HbA1c。结果（1）GGT在空腹GLU〉7．0mg／dl患者组的值显著高于正常体检组和空腹GLU〈7．0mg／dl患者组（P〈0．05）。（2）消除诸多的混杂因素后，GGT的四分位的最高层与最低层在三组间差异仍有统计学意义（P〈0．05）。结论GGT有望成为2型糖尿病患者治疗过程中预测疾病发展的指标。Objective To explore the association between serum gamma glutamyl transpeptidase （GGT） and fasting blood-glucose, evaluating the modification effects of body mass index （ BMI）, age, sex, and lipids. Methods The normal control group （120 cases）, the hospitalized patients with three times of the average fasting blood glucose （6. 0 - 7. 0 mg/dl） （128 cases）, and the hospitalized patients with three times of the average fasting blood glucose （ 〉 7. 0 mg/dl） （124 cases） were selected in this study. Immune turbidimetry was used to test the serum of GGT, aspartate aminotransferase （ AST）, alanine aminotrans- ferase （ ALT）, alkaline phosphatase （ ALP）, total cholesterol （ TC）, and triglycerides （TG）. Enzymatic method was used to test glucose （GLU）. High performance liquid chromatography-electrospray mass spec- trometry was used to measure glycosylated hemoglobin Alc （HbAlc） in the blood. Results （1） The value of GGT was significantly higher in the patients with type 2 diabetes, but the fasting blood glucose was above of 7.0 compared to the other two groups （ P 〈 0. 05）. （2） After adjustment of many confounders, the signif icance of the highest GGT quartile band compared to the lowest was obviously among three groups （ P 〈 0. 05）. Conclusions GGT is expected to predict the development of disease in the process of treatment of type 2 diabetes.

关 键 词：糖尿病  2型/代谢 γ-谷氨酰转移酶/代谢 血糖 

分 类 号：R587.1[医药卫生—内分泌] R446.1[医药卫生—内科学]