载脂蛋白M-1-磷酸鞘氨醇轴与血栓相关性疾病  

The relationship between the apolipoprotein M-sphingosine-l-phosphate axis and Thrombosis-relat- eddiseases

作　　者：申婷[1] 胡敏[1] 

机构地区：[1]中南大学湘雅二医院检验科,长沙410011

出　　处：《中国医师杂志》2016年第10期1596-1600,共5页Journal of Chinese Physician

摘　　要：载脂蛋白M-1-磷酸鞘氨醇轴（apoM-S1P）是一条由apoM、S1P和S1P受体组成的信号通路。apoM不仅能运载S1P，还能通过调节血浆S1P的浓度来激活不同的S1P受体信号通路。S1P受体信号通路对凝血功能的调节已较明确。近期的研究结果表明，apoM的表达水平与血栓性疾病的发生和发展也密切相关，虽然其中的机制仍然不清楚。apoM-S1P轴可能在血栓性疾病的发生和发展过程中发挥了重要作用。The apolipoprotein M-sphingosine-l-phosphate axis （apoM-S1P axis） is a signal path- way consists of apoM, S1P and S1 P receptors, apoM is not only capable of carrying S1 P, but also activates different S1P signal pathway through regulating S1P concentration in plamsa. It＇s clear that S1P signal path- way regulates the coagulation function of human beings. Furthermore, recent studies showed a strong con- nection between apoM and thrombosis-related diseases, although the underlying mechanism is unknown, Apo M-S1 P axis may play an important role in the pathogenesis and progression of thrombosis-related diseases.

关 键 词：载脂蛋白类/代谢 鞘氨醇/代谢 鞘磷脂类/代谢 血栓形成/代谢 综述 

分 类 号：R54[医药卫生—心血管疾病]