早中孕期胎儿颈项透明层增厚的病例分析  

Case Analysis of the First-trimester Thickening of Fetal Nuchal Translucency

作　　者：邓凤莲[1] 郭燕丽[1] 段灵敏[1] 冯玉洁[1] 薛雅方[1] 刘建君[1] 钟华[1] 

机构地区：[1]解放军第三军医大学附属西南医院超声科,重庆市400038

出　　处：《中国超声医学杂志》2016年第11期1007-1010,共4页Chinese Journal of Ultrasound in Medicine

基　　金："十二五"国家科技支撑计划项目(No.2014BA106B00)

摘　　要：目的探讨产前超声诊断胎儿颈项透明层(NT)增厚的临床价值。方法选取我院产前超声诊断的NT增厚胎儿171例,进行回顾性分析其声像图表现及临床资料。结果 NT增厚胎儿的发生率为0.76%,其中单纯NT增厚者占59.1%,合并其他结构异常者占40.9%。正常分娩存活96例,自然流产或胎死宫内11例,医疗性终止妊娠60例,失随访4例。103例胎儿行染色体核型分析,结果显示核型正常79例,核型异常24例。相关分析结果显示胎儿NT不同厚度与合并其他器官或结构异常和医疗性终止妊娠之间存在正相关,与死胎或自然流产和染色体异常不相关。结论 NT增厚对胎儿结构畸形、染色体异常有重要的预测价值,为临床预后评估和遗传咨询提供一定依据。Objective To investigate the clinical value of prenatal ultrasound in thickening of fetal nuchal translueency（NT）. Methods 171 fetuses with thickening NT were collected in South West Hospital. The ultrasonographic features and clinical data of NT thickening fetus were retrospectively analyzed. Results The incidence rate of fcruses with thickening NT was 0.76%. Among them, pure NT thickening was accounting for 59.1% and combined with other structural abnormalities was 40.9 %. In 171 fetuses, 96 cases had normal delivery, 11 cases were aborted or intrauterine death, 60 cases were medically terminated and 4 cases were lost to follow up. 103 cases underwent fetal kar yotype analysis, and the result showed normal chromosome karyotype in 79 cases and abnormal in 24 cases. Correlation analysis suggested that different thicknesses of NT were positively linked with other structural abnormalities and medical termination of pregnancy, while they were not associated with stillbirth or spontaneous abortion and chromosomal abnormalities. Conclusions The thickening NT has an important value in predicting fetal chromosomal diseases and fetal abnormalities. Therefore, NT thickening provides a basis for clinical prognosis and genetic counseling.

关 键 词：颈项透明层 产前超声 胎儿 诊断 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]