结核患者与卡介苗接种次数相关性断面监测及思考  

TB patients and the number of BCG vaccine correlation section monitoring and thinking

作　　者：卢立国[1] 严明月 孙婷婷[1] 裘强[2] 闫卫彬[1] 陈桃[1] 胡玉兰[1] 韩光[1] 蔡群[1] 戴举响 顾春湘[2] 叶隆昌[1] 

机构地区：[1]江苏省沭阳县人民医院,江苏宿迁223600 [2]江苏省泗洪县分金亭医院,江苏宿迁223900

出　　处：《临床医药文献电子杂志》2016年第28期5526-5529,共4页Electronic Journal of Clinical Medical Literature

摘　　要：目的 探讨儿童期接种卡介苗对成年后断面结核病发生的影响。方法 选取两个县在1980年1月1日-1985年12月31日出生时接种卡介苗,并且小学一年级、初中一年级各再加强1次接种的人群,通过对该人群卡疤抽样调查结果推算出这两个县该年龄段的未接种与接种及各接种次数的人数,并对该人群于2010-2014年间到结核病定点医院就诊被诊断为结核病者行卡介苗疤痕（卡疤）检查,利用SPSS17.0统计学软件对两人群中卡介苗不同接种次数结核病发生率比较的结果进行分析。结果 两个县1980-1985年出生231429人（观察人口）;2000年5月对其于高中一、二年级抽样3619名学生卡疤率为94.94%;监测期发现结核病人计169例,其中无卡疤者61例（36.09%）,1个的是63例（37.28%）,2个的是45例（26.63%）,3个及以上卡疤的均为0（0.00%）;经检验：未接种人群发病率（61/11710）与接种1次的（63/19625）比较,差异有统计学意义（x2〉6.63,P7.88,P〈0.005）。结论 儿童期接种卡介苗可能对成年后结核病（非血行播散型肺结核及结核性脑膜炎）有一定的保护作用;加强卡介苗接种可能对结核病有更好保护作用;因此,预防结核病儿童期接种卡介苗是需要的,加强接种可能更有意义;如果对结核病的高危成年人群和高龄人群接种卡介苗或许是有益和值得的。Objective To investigate the influence of childhood BCG vaccination for the adult＇s morbidity of tuberculosis （TB）.Methods From 13 counties （city, area） having about 10.5 million people totally, we select the persons who received the BCG vaccination when they were born between January 1, 1980 and December 31, 1985, and had the strengthen vaccination one time each in the elementary school grade one and junior high school grade one, as the sample. Then we made the BCG scar detection to the TB patients diagnosed by two of the county TB fixed-point hospital from 2010 to 2014. Through the result of the sampling survey on the BCG scar, we calculated the group number of vaccinated and unvaccinated groups at the age in the two counties, and used the SPSS17.0 statistical soft＇ware to have the statistical analysis to the compared results of the incidence of tuberculosis in two groups with different BCG vaccination.Results The population of the observed persons in two counties （born from 1980 to 1985） is 1980429. In May of 2000, the sampling survey of 3619 students in the first and second grade in a high school shows the result that the BCG scar rate is 94.94%, and during the observation period, there is 169 TB patients, in which 61 patients have no BCG scar （take up 36.09%）, 63 patients （37.28%） have 1 BCG scar, 45 patients （26.63%） have 2 BCG scars, and there is no patient with 3 or more BCG scars. Through examination： the unvaccinated morbidity （61/11 710） compared with the one-time vaccinated （63/19 625）, x2〉 6.63, p 〈 0.01. So there is statistical significance. The Comparison between the one-time vaccinated and the two-time vaccinated （45/116 386）, x2 〉 7.88, P〈0.05, which also has statistical significance.Conclusions Childhood BCG vaccination may have some protection to the adult tuberculosis （Non-blood line of disseminated tuberculosis and TB meningitis）.Strengthen the BCG vaccination might have better protective effect on tuberculosis. Therefore, in order to the

关 键 词：结核病 卡介苗 断面监测 思考 

分 类 号：R186[医药卫生—流行病学]