氟哌噻吨美利曲辛片治疗老年胶质瘤术后睡眠障碍的临床研究  

Clinical trial of flupentixol melitracen tablets in the treatment of postoperative sleep disorders in elderly patients with glioma

作　　者：廖珩[1] 毕丽杰[1] 魏君[1] 

机构地区：[1]唐山市工人医院神经外科,河北唐山063000

出　　处：《中国临床药理学杂志》2016年第21期1960-1963,共4页The Chinese Journal of Clinical Pharmacology

基　　金：唐山市医学科技计划基金资助项目(12130276b)

摘　　要：目的观察氟哌噻吨美利曲辛片对老年胶质瘤术后睡眠障碍患者血清5-羟色胺(5-HT)、抑郁自评量表(SDS)及甲状腺激素水平的影响。方法86例老年胶质瘤术后伴有睡眠障碍患者分为对照组43例与试验组43例。试验组口服氟哌噻吨美利曲辛10.5 mg,每日1次;对照组口服艾司唑仑1~2 mg,每日1次,2组疗程均为4周。比较2组患者治疗前后血清5-HT、匹兹堡睡眠质量指数量表(PSQI)、SDS评分及甲状腺激素水平。结果试验组的总有效率为93.02%(40/43例),对照组的总有效率为76.74%(33/43例,P<0.05)。治疗后,试验组PSQI为(8.04±1.12)分,对照组为(11.74±1.32)分;试验组SDS为(37.62±5.60)分,对照组为(46.82±6.23)分;试验组促甲状腺素(TSH)为(6.23±0.62)m U·L^(-1),对照组为(7.16±0.78)m U·L^(-1);试验组游离三碘原氨酸(FT3)为(6.62±0.89)pmol·L^(-1),对照组为(7.43±1.06)pmol·L^(-1);试验组游离甲状腺素(FT4)为(15.63±2.61)pmol·L^(-1),对照组为(18.92±3.57)pmol·L^(-1),2组差异有统计学意义(P<0.05)。治疗后,试验组5-HT为(109.37±11.26)μmol·L^(-1),对照组为(154.05±17.49)μmol·L^(-1)(P<0.05)。药物不良反应主要表现为头痛、口干,试验组药物不良反应发生率为6.98%(3/43例),对照组药物不良反应发生率为2.33%(1/43例),差异无统计学意义(P>0.05)。结论氟哌噻吨美利曲辛能明显改善老年胶质瘤术后睡眠障碍患者的睡眠质量,降低抑郁程度,安全性高。Objective To investigate the clinical efficacy of flupentixol melitracen in the treatment of postoperative sleep disorders in elderly pa- tients with glioma. Methods Eight- six sleep disorders elderly patients with glioma were randomly divided into control group and treatment group, 43 cases each. Treatment group received flupentixol melitracen 10. 5 mg orally qd, and control group received estazolam 1 -2 mg orally qd for 4 weeks. Serum 5 - hydroxytryptamine （ 5 - HT）, Pittsburgh sleep quality index （PSQI） , self - rating depression scale （SDS） and thyroid hormone levels were compared between the two groups. Results Total efficacy of treatment group was 93.02% （40/43）, had significant difference with 76. 74% （ 33/43 ） in control group （ P 〈 0. 05 ）. The levels of PSQI, SDA in treatment group were 8.04 ± 1.12, 37. 62 ± 5. 60, had significant difference with 11.74 ± 1.32, 46. 82 ± 6. 23 in control group （P 〈 0. 05）. The levels of thyrotropin （TSH） , three iodine free triiodothyronine （ FT3 ） and free thyroxine （ F-F4 ） in treatment group were （6.23 ±0. 62） mU L-1, （6.62 ±0. 89） pmol L-1, （15.63 ±2. 61） pmol L-1, had signi- ficant difference with （7.16 ±0.78） mU L-1, （7.43 ± 1.06） pmol L-1, （18.92 ± 3.57） pmol. L-1 in control group （P 〈 0. 05 ）. After treatment, serum level of 5 - HT in treatment group was （ 109.37 ± 11.26） μmol L-1, had significant difference with （154. 05 ± 17.49） μmol L-1 in control group （P 〈0. 05）. Adverse drug reactions mainly manifested as headache, dry mouth, the incidence of adverse drug reactions in treatment and control group were 6. 98% （3/43） , 2. 33% （ 1/43, P 〉 0. 05）. Conclusion Flupentixol melitracen in postoperative sleep disorders in elderly patients with glioma was effective with high safety.

关 键 词：氟哌噻吨美利曲辛 睡眠障碍 胶质瘤 甲状腺激素 

分 类 号：R971.3[医药卫生—药品]