降钙素原及抗炎、促炎因子在胆道梗阻患者早期胆道感染诊断中的应用研究  

Clinical application of procalcitonin,anti-inflammatory and pro-inflammatory factors in diagnosis of early biliary tract infections in patients with biliary obstruction

作　　者：曾鹏飞[1] 主鹤亭[1] 冯春林[1] 贾继虎[1] 冷凯[1] 罗燕青[1] 

机构地区：[1]遵义医学院第三附属医院肝胆胰病区,贵州遵义563000

出　　处：《中华医院感染学杂志》2016年第22期5166-5168,共3页Chinese Journal of Nosocomiology

基　　金：贵州省省长基金资助项目(黔省专合字[2012]120号)

摘　　要：目的探究降钙素原(PCT)及抗炎因子(IL-4、IL-10及IL-13)、促炎因子(IL-1β、IL-6及TNF-α)在胆道梗阻患者早期胆道感染中的临床应用效果,以了解上述指标在胆道梗阻患者早期胆道感染中的检测意义。方法选取2014年6月-2016年3月医院收治42例胆道梗阻早期胆道感染患者为A组,42例胆道梗阻无感染患者为B组,42名体检健康者为C组,将3组受试者血清PCT及IL-4、IL-10、IL-13,IL-1β、IL-6及TNF-α水平进行比较,同时比较A组中不同感染部位与严重程度胆道感染者的检测结果。结果 A组血清PCT及IL-4、IL-10、IL-13,IL-1β、IL-6及TNF-α分别为(11.35±1.45)ng/ml、(46.75±3.79)ng/ml、(21.61±2.45)pg/ml、(22.72±2.38)pg/ml、(2.63±0.25)pg/ml、(8.95±0.73)pg/ml及(2.71±0.22)ng/ml,其均高于B组(8.79±1.23)ng/ml、(40.26±3.48)ng/ml、(16.38±1.64)pg/ml、(15.45±1.57)pg/ml、(1.87±0.19)pg/ml、(6.78±0.61)pg/ml、(1.59±0.17)ng/ml及C组(0.65±0.10)ng/ml、(30.13±3.25)ng/ml、(8.78±1.23)pg/ml、(7.87±0.95)pg/ml、(1.10±0.13)pg/ml、(3.31±0.40)pg/ml、(0.75±0.12)ng/ml,B组则高于C组,且A组中不同严重程度胆道感染者检测结果也存在明显差异,差异有统计学意义(P<0.05)。结论 PCT及IL-4、IL-10、IL-13,IL-1β、IL-6及TNF-α在胆道梗阻患者早期胆道感染中的临床检测价值较高,对于疾病的诊断与治疗均有临床指导意义。OBJECTIVE To explore the clinical effect of procalcitonin （PCT ） ,anti‐inflammatory factors （IL‐4 ,IL‐10 ,and IL‐13） ,and pro‐inflammatory factors （IL‐1β,IL‐6 ,and TNF‐α） on diagnosis of early biliary tract infec‐tions in patients with biliary obstruction so as to understand the significance of detection of the above indexes for the biliary obstruction patients with early biliary tract infections .METHODS Totally 42 biliary obstruction patients with early biliary tract infections who were treated in the hospital from Jun 2014 to Mar 2016 were assigned as the group A ,42 biliary obstruction patients without infections were set as the group B ,and 42 healthy people who re‐ceived physical examination were set as the group C .The levels of serum PCT ,IL‐4 ,IL‐10 ,IL‐13 ,IL‐1β,IL‐6 , and TNF‐αwere compared among the three groups of participants ,meanwhile ,the detection results were observed and compared among the patients with different sites of infection or the patients with different severities of biliary tract infection in the group A .RESULTS The levels of serum PCT ,IL‐4 ,IL‐10 ,IL‐13 ,IL‐1β,IL‐6 ,and TNF‐αof the group A were respectively （11 .35 ± 1 .45）ng/ml ,（46 .75 ± 3 .79）ng/ml ,（21 .61 ± 2 .45）pg/ml ,（22 .72 ± 2 .38）pg/ml ,（2 .63 ± 0 .25）pg/ml ,（8 .95 ± 0 .73）pg/ml ,and （2 .71 ± 0 .22）ng/ml ,higher than （8 .79 ± 1 .23）ng/ml ,（40 .26 ± 3 .48）ng/ml ,（16 .38 ± 1 .64）pg/ml ,（15 .45 ± 1 .57）pg/ml ,（1 .87 ± 0 .19）pg/ml ,（6 .78 ± 0 .61）pg/ml ,and （1 .59 ± 0 .17）ng/ml of the group B and （0 .65 ± 0 .10）ng/ml ,（30 .13 ± 3 .25）ng/ml ,（8 .78 ± 1 .23）pg/ml ,（7 .87 ± 0 .95）pg/ml ,（1 .10 ± 0 .13）pg/ml ,（3 .31 ± 0 .40）pg/ml ,and（0 .75 ± 0 .12）ng/ml of the group C ;the levels of the above indexes of the group B were higher than those of the group C ;the detection results varied significantly among the patients with different severities of biliary tract infect

关 键 词：降钙素原 抗炎因子 促炎因子 胆道梗阻 早期胆道感染 

分 类 号：R446[医药卫生—诊断学]