经皮冠状动脉介入治疗不稳定型心绞痛应用阿托伐他汀联合曲美他嗪对炎性因子的影响  

Therapeutic effects of atorvastatin combined with trimetazidine on unstable angina pectoris treated by percutaneous coronary artery intervention

作　　者：高秋[1] 杨松[1] 陈燕春[1] 周维[1] 

机构地区：[1]江苏省宜兴市人民医院心血管内科,214200

出　　处：《河北医药》2016年第21期3227-3229,3233,共4页Hebei Medical Journal

摘　　要：目的观察中西医结合药物治疗的基础上应用运动疗法与单纯应用药物治疗心绞痛患者的临床疗效情况。方法选取2014年7月至2015年8月收治的80例不稳定型心绞痛患者,分为观察组和对照组,每组40例,对照组患者采用阿托伐他汀治疗;观察组患者采用阿托伐他汀联合曲美他嗪治疗。比较2组疗效、炎性因子水平、血脂、生活质量评分。结果观察组总有效率92.5%高于对照组的72.5%,差异有统计学意义(P<0.05)。治疗前,2组患者肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)及超敏C-反应蛋白(hs-CRP)水平差异无统计学意义(P>0.05);治疗后,观察组患者TNF-α水平下降,而对照组患者TNF-α水平上升;观察组患者IL-6水平降低幅度比对照组大;观察组患者hs-CRP水平降低,而对照组患者hs-CRP水平增高,差异有统计学意义(P<0.05)。治疗前,2组患者血脂TC、TG、HDL-C、LDL-C水平差异无统计学意义(P>0.05);治疗后,观察组患者血脂TC、TG、LDL-C水平降低幅度大于对照组;观察组患者血脂HDL-C水平上升幅度大于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者生活质量评分差异无统计学意义(P>0.05);治疗后,观察组患者生活质量评分上升幅度比对照组大,差异有统计学意义(P<0.05)。结论阿托伐他汀联合曲美他嗪在经皮冠状动脉介入治疗不稳定型心绞痛疗效显著,能有效降低炎性因子水平及降低血脂,提高患者生活质量。Objective To observe the therapeutic effects of atorvastatin combined with trimetazidine on unstable angina pectoris treated by percutaneous coronary artery intervention,and to observe the changes of inflammatory factors during treatment. Methods Eighty patients with unstable angina pectoris who were admitted and treated in our hospital from July2014 to August 2015 were divided into observation group（ n = 40） and control groups（ n = 40） by means of random number table method. The 40 patients in control group were treated by atorvastatin,however,the other 40 patients in observation group were treated by atorvastatin combined with trimetazidine. After treatment,the therapeutic effects,levels of inflammatory cytokines,blood lipid,life quality of patients were observed and compared between two groups. Results After treatment,the total effective rate in observation group was 92. 5%,which was significantly higher than that（ 72. 5%） in control group（ P〈0. 05）. Before treatment there were no significant differences in the levels of TNF-α,IL-6,hs-CRP between two groups（ P〈0. 05）. After treatment,the levels of TNF-α in observation group were decreased,however,which in control group were increased,morever,the levels of IL-6 in observation group were significantly decreased,as compared with those in control group. The levels of hs-CRP in observation group were decreased,however,which in control group were increased,there were significant differences between two groups（ P〈0. 05）. The decrease degree of IL-6 levels in observation group was greater than that in control group. The levels of hs-CRP in observation group were decreased,however,which in control group were increased,there were significant differences between two groups（ P〈0. 05）. Before treatment,there were no significant differences in the levels of TC,TG,HDL-C,LDL-C between two groups（ P〉0. 05）. After treatment,the levels of TC,TG,LDL-C in observation group were significantly decreased,as compared with those in control gr

关 键 词：阿托伐他汀 曲美他嗪 心绞痛 炎性因子 

分 类 号：R541.42[医药卫生—心血管疾病]