2型糖尿病易感基因代谢通路生物信息学研究  

Metabolic pathways research of susceptibility genes of diabetes by bioinformatics

作　　者：张丽杰[1,2] 裴智勇[1,2] 马跃 陈禹保[1,2,4] 

机构地区：[1]北京市计算中心,100094 [2]云计算关键技术与应用北京市重点实验室,100094 [3]北京小汤山医院,102211 [4]北京市测序与功能分析工程技术研究中心,100094

出　　处：《国际检验医学杂志》2016年第21期2996-2998,3001,共4页International Journal of Laboratory Medicine

基　　金：北科院创新团队项目(IG201406C1);北京市计算中心萌芽计划项目;北京市优秀人才青年骨干项目(2015400685627G238)

摘　　要：目的构建中国人群中2型糖尿病易感基因的代谢通路。方法采用2型糖尿病的易感基因集合,基于商用数据库Ingenutiy Pathway Analysis(后简称IPA)中的Right-Tailed Fisher′s Exact Test算法进行统计分析,找到与糖尿病相关的代谢通路,并从中筛选出15个与中国人群糖尿病相关的易感基因,根据易感基因建立代谢通路,探讨中国人群易感基因之间在生物学上的关联关系。结果 KCNQ1、PPARG、IRS1、ADIPOQ等基因位于多条代谢通路的节点位置,与多条代谢通路相关。结论 KCNQ1、PPARG、IRS1、ADIPOQ等基因在中国人群2型糖尿病的发生过程中起到了关键作用。该研究结果对基于代谢通路研究复杂性疾病具有很好的借鉴意义。Objective To build a complicated metabolic pathway based on susceptibility genes in China and to explore the biological relationship in Chinese susceptibility genes.Methods By a set of susceptibility genes in type 2 diabetes and based on RightTailed Fisher′s Exact Test algorithm of Ingenutiy Pathway Analysis（IPA）,diabetes-related metabolic pathways were founded.And15 susceptibility genes which related to Chinese diabetes had been screened out.Based on these susceptibility genes a complex metabolic pathway had been built to explore the relationship between biological susceptibility genes in the Chinese population.ResultsKCNQ1,PPARG,IRS1 and ADIPOQ genes were located more than one biological pathway node positions,and the genes were related with a plurality of metabolic pathways.Conclusion KCNQ1,PPARG,IRS1 and ADIPOQ genes play a vital role in the occurrence of type 2diabetes in Chinese people.The result is a good reference for research on complex diseases based on metabolic pathways.

关 键 词：2型糖尿病 易感基因 代谢通路 

分 类 号：R587.1[医药卫生—内分泌]