双环吡咯酮类化合物的简便合成  

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

作　　者：孔令斌[1] 杨瑞霞[1] 杜璇璇[1] 严胜骄[1] 林军[1] 

机构地区：[1]云南大学化学科学与工程学院教育部自然资源药物化学重点实验室,昆明650091

出　　处：《有机化学》2016年第10期2437-2441,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.U1202221;21362042;21662042);云南省后备人才(No.2012HB001);云南大学青年英才计划(No.XT412003)资助项目~~

摘　　要：建立了一锅法合成双环吡咯酮化合物的方法.该方法以杂环烯酮缩胺1为合成砌块,在1,4-二氧六环溶剂中,三乙胺作碱,与乙二醛在50℃下反应,一步法关环合成了双环吡咯酮类化合物3a^3i.该方法具有合成路线简洁、后处理简单、原料易得、产率高和操作简便等优点.In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50℃ and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a-3i have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures.

关 键 词：双环吡咯酮 杂环烯酮缩胺 乙二醛 

分 类 号：O626.13[理学—有机化学]