我院6382例药品不良反应报告的回顾性分析  

Analysis of 6382 Cases of Adverse Drug Reaction Reports in Our Hospital

作　　者：胡晓蕾[1] 杨雅[1] 李薇[1] 江灏[1] 汤怡然[1] 符佩姝 何菊英[1] Hu Xiaolei Yang Ya Li Wei Jiang Hao Tang Yiran Fu Peishu He Juying(Department of Pharmacy, The First Affiliated Hospital of Third Military Medical University, Chongqing 400038, Chin)

机构地区：[1]第三军医大学第一附属医院药学部,重庆400038

出　　处：《药物流行病学杂志》2016年第10期640-642,649,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：分析药品不良反应（ADR）发生特点及规律,为临床安全用药提供参考。方法：对2009-2015年我院收集的共6 382份ADR进行回顾性分析,分别按患者的年龄、性别、给药途径、药品种类、严重程度及ADR临床表现等进行分类统计。结果：6 382例ADR报告的男女患者比例为1∶1.07,41岁以上中老年患者所占比例最高（〉60%）。一般的ADR报告数量最多,报告主体为医生（91.21%）;静脉用药引发ADR有5 100例（79.91%）,单一用药引发占88.55%;ADR主要导致消化系统损害（45.46%）;ADR涉及22类药物,肿瘤药物居首位（1 677例,占26.28%）;奥沙利铂（34.43%）、氨甲环酸（11.52%）和复方氨基酸（20AA）（9.65%）位列引起ADR的单品种前3位;严重不良反应共104例,以肿瘤药物（36.54%）和抗感染药（25.00%）为主。结论：临床工作中应重视ADR报告与监测,促进安全用药。Objective ： To analyze the characteristics and rules of adverse drug reaction （ADR） and provide refer- ences for clinical rational and safe drug use. Methods： 6 382 cases of ADR reports collected from 2009 to 2015 were ana- lyzed retrospectively and statistically. Classified statistics respectively according to the patient＇ s age, sex, drug delivery route, drug type, severity and ADR clinical manifestation, etc. Results：Among the 6 382 ADR cases,the male to female ratio was 1 ： 1.07, mainly in over 41 years of age and older patients（ 〉60% ）. The number of general ADR report is the most, and the doctor is the main body of the report（91.21% ）. 5 100 cases（79.91% ） were given intravenously and with a single drug cause（88.55% ）. ADRs mainly involved the digestive system damage（45.46% ）. ADR cases referred to 22 categories of drugs, Of which antineoplastic agents occupied the first place which had 1677 cases （26.28%）. Oxaliplatin （ 34.43 % ）, tranexamic acid （ 11.52% ） and compound amino acid （20AA） （9.65 % ） were the top three among suspec- ted drugs. 104 cases were severe, of which antineoplastic agents occupied the first place （36.54%）, followed by anti-in- fective agents（25.00% ）. Conclusion： In clinical work, we should pay attention to the report and monitoring of ADR, and promote the safe use of drugs.

关 键 词：药品不良反应 报告 回顾性分析 

分 类 号：R951[医药卫生—药学]