207例药源性过敏性休克分析  

Analysis of 207 Reports of Drug-induced Anaphylactic Shock

作　　者：孙旌文 Sun Jingwen(Fuyang Center for Food Medical Devices Adverse Drug Reaction/Events Monitoring, Fuyang 236029, Anhui, Chin)

机构地区：[1]阜阳市食品药品医疗器械不良反应/事件监测中心,安徽阜阳236029

出　　处：《药物流行病学杂志》2016年第10期643-646,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：分析药源性过敏性休克发生的一般规律及抢救措施,为临床安全用药提供参考。方法：对阜阳市药品不良反应监测中心2011-2014年收到的207例过敏性休克病例报告,按照患者性别、年龄、过敏性休克发生时间、给药途径、怀疑药品、抢救药物和过敏性休克转归等情况进行回顾性分析。结果：导致过敏性休克的可疑药物中,抗微生物药、中药注射剂、血液系统药构成比居前3位;静脉用药所占比例最高（91.3%）;过敏性休克大多数发生在用药后20 min内,占84.5%。结论：临床应重视药源性过敏性休克的发生,用药前询问过敏史,严格掌握用药指征,注意用药全程的监护,一旦出现不良反应及时停药,并采取适当措施予以对症抢救治疗。Objective：To analyze the general regularity and rescue measures of the drug-induced anaphylactic shock,provide references for clinical safe use of medicine.Methods：207 reports of anaphylactic shock in Fuyang center for food medical devices adverse drug reaction/events monitoring from 2011 to 2014,were retrospective analyzed in terms of genders and ages,shock time,route of medication,suspected drug,first aid drugs,and anaphylactic shock outcome.Results：Anti-microbial drugs,Traditional Chinese Medicine injections and blood system drugs were the top three position.The constituent ratio of intravenous drug was the highest,accounting for 91.3%.The majority of anaphylactic shock occurred within 20 minutes after administration,accounting for 84.5%.Conclusion：The clinical should pay attention to drug-induced anaphylactic shock,strict indications medication,strengthen the guardianship medication.

关 键 词：药品不良反应 过敏性休克 回顾性分析 

分 类 号：R593.1[医药卫生—内科学]