液基薄层细胞学检测技术及传统宫颈细胞涂片在宫颈癌筛查中的临床应用对比研究  

Clinical application of thinprep cytology test and traditional cervical cell smear in cervical cancer screening

作　　者：陈红球 施晓 钱立勇 

机构地区：[1]舟山巿妇幼保健院妇科,浙江舟山316000

出　　处：《中国性科学》2016年第10期39-41,共3页Chinese Journal of Human Sexuality

摘　　要：目的:比较液基薄层细胞学检测技术(TCT)与传统巴氏涂片在宫颈癌筛查中的应用效果。方法:选取2013年4月至2015年4月我院收治的1826例患者作为本次研究的对象,接受TCT法的1742例患者纳入TCT组,接受传传统巴氏涂片的84例患者纳入对照组,通过患者的组织病理活检结果,分析并比较两组检查的准确率。结果:TCT组阳性符合率为75.89%(1322/1742),对照组为53.57%(45/84),两组间阳性符合率差异有高度显著性意义(χ2=671.03,P<0.01);两组检查方法指标相比,特异度均为100%无差异(P>0.05),而TCT组敏感度和阴性预测值均显著高于对照组(χ2=671.03、5.10,P<0.01或0.05)。结论:TCT应用于宫颈癌筛查中效果好,虽然费用略高,但其敏感度显著优于传统的巴氏涂片法,具有在临床上推广的价值。Objectives： To compare the application value of thinprep cytology test（ TCT） and traditional cervical cell smear in cervical cancer screening. Methods： 1826 patients treated in our hospital from April 2013 to April 2015 were included in the study,the 1742 cases treated with TCT as the TCT group and the 84 patients received traditional pap smear as the control group. The accuracy rate was compared through analyzing the pathological biopsy results. Results： Difference in cytology positive rate between the two groups was significant（ χ2= 81. 88,P〈 0. 01）. The positive coincidence rate in TCT group and control group was 75. 89%（ 1322 /1742） and 53. 57%（ 45 /84） respectively,with significant difference（ χ2= 671. 03,P〈 0. 01）. The specificity of test index in both groups was 100%,without difference（ P〈 0. 05）,and the sensitivity and negative predictive value of TCT group was significantly higher than control group（ χ2= 671. 03,5. 10,P〈 0. 01 or 0. 01）. Conclusion： TCT is of highapplication value in cervical cancer screening. Although the cost was slightly higher,the sensitivity was significantly superior to the traditional pap smear method,worthy of promotion in clinical.

关 键 词：液基薄层细胞学 传统巴氏涂片 宫颈癌 筛查 

分 类 号：R44[医药卫生—诊断学] R737.33[医药卫生—临床医学]