CO_2激光联合5%咪喹莫特乳膏治疗女性尖锐湿疣临床效果观察  

Clinical effects of imiquimod and CO_2 laser in the treatment of female condyloma acuminatum

作　　者：周均 王翠媚 罗丽丽 于娜莎 钟庆杨[3] 

机构地区：[1]东莞石碣医院皮肤科,广东东莞523290 [2]南方医院皮肤科,广州510515 [3]东莞市人民医院感染科,广东东莞523000

出　　处：《中国性科学》2016年第10期77-80,共4页Chinese Journal of Human Sexuality

基　　金：广东省东莞市科技计划项目(2013108101033)

摘　　要：目的:考察CO_2激光联合5%咪喹莫特乳膏治疗女性尖锐湿疣临床效果。方法:将60例女性尖锐湿疣患者随机分为观察组和对照组,每组30例。对照组给予CO_2激光联合阿昔洛韦软膏治疗,观察组患者给予CO_2激光联合5%咪喹莫特乳膏治疗。1个月为1个疗程,治疗1个疗程,随访3个月。比较两组患者治疗有效率、不良反应和复发率。结果:观察组患者有效率为96.7%(29/30)显著高于对照组的80.0%(24/30)(χ2=4.043,P<0.05)。观察组患者出现13例(43.3%)不良反应与对照组的12例(40.0%)相比差异无统计学意义(χ2=0.069,P>0.05)。随访期间观察组脱组1例、对照组脱组2例,观察组患者复发2例(6.7%)显著低于对照组的8例(26.7%)(χ2=4.320,P<0.05)。结论:CO_2激光联合5%咪喹莫特乳膏治疗女性尖锐湿疣有效率更高且复发率低,具有临床应用价值。Objectives： To investigate theCO_2laser combined with 5% Imiquimod Cream in the treatment of female condyloma acuminatum. Methods： 60 female with condyloma acuminatum were randomly divided into observation group and control group,30 cases in each group. The control group was treated byCO_2laser combined with acyclovir ointment and observation group were treated withCO_2laser combined with 5% imiquimod cream,a month as a course of treatment. All patients were followed up for three months. The treatment efficiency,adverse reactions and recurrence rate were compared between two groups. Results： The effective rate of the observation group was 96. 7%（ 29 /30） which significantly higher than 80. 0%（ 24 /30） in control group（ χ2= 4. 043,P〈 0. 05）.There were 12 cases of adverse reaction in observation group which had no significant difference from the 13 cases in control group（ χ2= 0. 069,P〉 0. 05）. During the follow- up period,a case in the observation group and 2 cases in the control group were lost. There were 2 cases of recurrence in the observation group,significantly lower than the8 cases in control group（ χ2= 4. 320,P〈 0. 05）. Conclusion：CO_2laser combined with 5% imiquimod cream in the treatment of female condyloma acuminatum has higher efficiency and lower recurrence rate,worthy of clinical application.

关 键 词：尖锐湿疣 CO_2激光 咪喹莫特乳膏 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]