抗病毒治疗的HIV/AIDS病人生存状况的影响因素  

Review of the survival analysis of HIV/AIDS patients receiving highly active antiretroviral therapy

作　　者：张继红[1] 董红军[2] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市疾病预防控制中心,浙江宁波315010

出　　处：《中国艾滋病性病》2016年第9期759-762,共4页Chinese Journal of Aids & STD

摘　　要：随着艾滋病(AIDS)高效抗反转录病毒治疗(HAART)时间的积累,艾滋病病毒(HIV)感染者/AIDS病人(简称HIV/AIDS病人)生存状况及影响因素分析,成为近年来国内外艾滋病研究领域关注的热点和重点。研究常用回顾性队列研究方法,采用寿命表法计算生存率,并绘制相关影响因子的Kaplan-Meier生存曲线。Cox比例风险回归模型单因素和多因素分析显示,年龄、性别、婚姻状况、BMI指数、感染途径、世界卫生组织的临床分期、基线CD4+T淋巴细胞水平等,是影响艾滋病抗病毒治疗生存时间的危险因素。针对重点人群加大艾滋病抗病毒治疗的宣传力度,早发现早诊断早治疗,提高治疗覆盖率,可以有效保障治疗效果,延长病人生存时间。Along with the progress of highly active antiretroviral therapy （HAART） for HIV/AIDS patients, more and more researches highlight the elements impacting on mortality and survival condition. Retrospective cohort studies are usually conducted with survival rate calculated through life table and different influence factors described by Kaplan-Meier curves. Bivariate and multivariable Cox proportional hazards regression models show that age, sex, marital status, BMI, route of transmission, clinical stages, baseline CD4 count are usually identified as the independent predictors of mortality. We should enhance the awareness of HAART targeting people living with HIV/ AIDS. The strategy of early detection, early diagnosis and early treatment is helpful to increase treatment coverage, which can effectively guarantee treatment effect and prolong survival time of HIV/AIDS patients.

关 键 词：艾滋病病毒感染者/艾滋病病人 高效抗反转录病毒治疗 生存时间 影响因素 

分 类 号：R512.91[医药卫生—内科学]