小儿肠道外感染性疾病应用抗生素后肠道菌群失调的临床分析  

Clinical analysis of enteric flora imbalance after antibiotics use for parenteral infection diseases among infants

作　　者：王玉瑛[1] 张孝兴[1] 汤淑斌[1] 焦爱萍[1] 高怡玢[2] 庞伟斌[3] 刘莹[2] 

机构地区：[1]宝鸡市妇幼保健院儿童医院儿科,陕西宝鸡721000 [2]宝鸡市妇幼保健院儿童医院检验科,陕西宝鸡721000 [3]宝鸡市妇幼保健院儿童医院细菌室,陕西宝鸡721000

出　　处：《中国妇幼健康研究》2016年第9期1114-1116,共3页Chinese Journal of Woman and Child Health Research

基　　金：宝鸡市卫生局科研立项资助项目(2012-42)

摘　　要：目的探讨小儿肠道外感染性疾病应用抗生素对肠道菌群的影响。方法回顾性分析2013年1月至2014年8月期间在宝鸡市妇幼保健院治疗的非肠道性感染患儿149例,对患儿应用抗生素治疗前及治疗第1天、3天、7天、14天的粪便进行细菌学分析,对比同期健康体检患儿的粪便细菌学情况,分析肠道菌群差异及肠道菌群失调比例。结果小儿非肠道感染性疾病应用抗生素后发生肠道菌群失调的比例为64.43%,均为Ⅰ度、Ⅱ度肠道菌群失调,无Ⅲ度菌群失调发生;婴儿组应用抗生素后发生肠道菌群失调的比例最高,差异均具有统计学意义（χ~2=8.89,P〈0.05）。相较于健康小儿肠道菌群,肠道菌群失调患儿主要组成菌群比例与健康小儿比较变化明显,差异具有统计学意义（χ~2=102.73,均P〈0.01）。结论对小儿,尤其是婴儿应尽可能使用窄谱抗生素,缩短抗生素使用时间,保护小儿正常肠道菌群。Objective To investigate the influence of antibiotics application for parenteral infection on intestinal flora. Methods A retrospective analysis was conducted on 149 cases of children treated in Baoji Maternity and Child Health Hospital for parenteral infection during the period of January 2013 to August 2014. The bacteriological analysis was carried out on feces of children before using antibiotics and ld, 3d, 7d and 14d after using them, and they were compared to those of healthy children selected in the same period. The difference in intestinal flora and the proportion of enteric flora imbalance were analyzed. Results The proportion of children suffering enteric flora imbalance after use of antibiotics for parenteral infection was 64.43% , and they were I and II degree of enteric flora imbalance. No case was found with dysbaeteriosis of l]I degree. The proportion of cases with enteric flora imbalance was highest in infant group, and the difference was statistically significant （X2 = 8.89, P 〈 0.05 ）. The differences in main composition of flora between cases of enteric flora imbalance and healthy cases were statistically significant （X2 = 102.73, both P 〈 0.01 ）. Conclusion For children, especially infants, narrow spectrum antibiotics should be given as far as possible, and the duration of antibiotics use should be shortened to protect the normal intestinal flora.

关 键 词：小儿 非肠道感染性疾病 抗生素 肠道菌群失调 

分 类 号：R725.7[医药卫生—儿科]