非布司他对痛风合并高尿酸血症患者血清sICAM-1,ET-1及尿酸水平的影响  

Effects of Febuxostat on the Seum sICAM-1, ET-1 and Uric Acid Levels of Patients with Gout and Hyperuricemia

作　　者：张文[1] 解为慈 徐金娥[1] 刘文[1] 张先君[1] 

机构地区：[1]湖北科技学院附属天门医院内分泌科,湖北天门431700

出　　处：《现代生物医学进展》2016年第27期5303-5305,共3页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(2002AB116)

摘　　要：目的:探讨非布司他对痛风合并高尿酸血症患者血清内皮素-1(ET-1)、细胞间粘附分子-1(ICAM-1)及尿酸水平的影响。方法:收集在我院就诊或住院治疗的80例痛风合并高尿酸血症患者,随机分为实验组和对照组,每组40例。对照组患者给予别嘌呤醇片治疗;实验组患者给予非布司他片治疗。观察并比较两组患者治疗前后血尿酸、s ICAM-1、ET-1水平及临床疗效。结果:与治疗前相比,两组患者治疗后的血尿酸、s ICAM-1、ET-1水平均显著降低(P<0.05);与对照组相比,实验组患者的血尿酸、s ICAM-1、ET-1水平较低(P<0.05),临床治疗总有效率较高(P<0.05)。结论:非布司他能够降低痛风合并高尿酸血症的s ICAM-1、ET-1及尿酸水平,且临床疗效较好。Objective： To evaluate the effect of febuxostat on gout and hyperuricemia, uric acid and Endothelin-1（ET-1） and intercellular adhesion molecule-1（ICAM-1）. Methods： Collected in our hospital or hospital treatment of 80 cases of gout and hyperuricemia were randomly divided into experimental group and control group, 40 cases in each group. Patients in control group were treated with 0.1g/ times, 3 times /d, oral; the experimental group were given times 80mg/ times, 1 times /d, oral administration. Treatment for 8 consecutive weeks. After the end of the treatment, the blood uric acid, s ICAM-1, ET-1 and the patients’ curative effect were detected and compared. Results： Compared with that before treatment and after treatment of two groups of patients with blood uric acid, s ICAM-1 and ET-1 levels lower（P〈0.05）; compared with the control group, blood uric acid, s ICAM-1 and ET-1 levels of the patients in the experimental group were lower（P〈0.05）, clinical treatment and the total effective rate was higher（P〈0.05）. Conclusion： Febuxostat can reduce gout and hyperuricemia, uric acid and s ICAM-1 ET-1, clinical curative effect is good, has the guiding sense to the clinical.

关 键 词：非布司他 痛风 高尿酸血症 内皮素-1 细胞间粘附分子-1 尿酸 

分 类 号：R589.7[医药卫生—内分泌]