神经根管减压术对中老年退行性腰椎管狭窄的临床疗效及机制研究  

Clinical Efficacy of Nerve Root Canal Decompression on Senile Patients with Degenerative Lumbar Spinal Stenosis and Its Mechanisms

作　　者：任龙龙[1] 张军武[1] 马永刚[1] 高智[1] 李天清[2] 王林[2] 

机构地区：[1]榆林市第二医院骨科,陕西榆林719000 [2]第四军医大学附属西京医院骨科,陕西西安710032

出　　处：《现代生物医学进展》2016年第27期5367-5369,共3页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2001SM79)

摘　　要：目的:探究神经根管减压术对中老年退行性腰椎管狭窄的临床疗效及其机制。方法:收集我院收治的中老年退行性腰椎管狭窄患者112例,根据随机数字对照表分为对照组与试验组,每组各56例。对照组采用保守治疗方法,试验组实施神经根管减压术。治疗结束后,比较两组患者的临床疗效、治疗前后血清炎症因子-1α(IL-1α)、肿瘤坏死因子(TNF-α)水平。结果:与对照组相比,试验组实施神经根管减压术总有效率较高(P<0.05)。与治疗前比较,两组治疗后血清IL-1α及TNF-α水平降低,且试验组血清IL-1α及TNF-α水平较对照组更低,差异均具有统计学意义(P<0.05)。结论:与保守治疗相比,神经根管减压术治疗中老年退行性腰椎管狭窄治愈率较高,可能与其显著降低血清IL-1α及TNF-α水平有关。Objective： To investigate the clinical effects and mechanisms of nerve root canal decompression on senile patients with degenerative lumbar spinal stenosis. Methods： 112 cases of patients with senile degenerative lumbar spinal stenosis from our hospital were collected and randomly divided into the control group and experimental group with 56 cases in each group. Patients in the control group were treated by conservative treatment, while patients in the experimental group were treated by nerve root canal decompression.The clinical efficacy, serum inflammatory factors such as tumor necrosis factor-α level of both groups before and after treatment were compared between two groups. Results： Compared with the control group, the total effective rate of nerve root canal decompression was higher. Compared with before treatment, the serum IL-1 and TNF- levels of both groups were decreased after treatment（P〈0.05）, which were lower in the experimental group than those of the control group（P〈0.05）. Conclusion： Compared with conservative treatment, the cure rate of nerve root canal decompression in the treatment of senile degenerative lumbar spinal stenosis was higher, which might be related to the decrease of serum IL-1 and TNF-α.

关 键 词：神经根管减压术 中老年退行性腰椎管狭窄 血清炎症因子-1α 肿瘤坏死因子-Α 

分 类 号：R68[医药卫生—骨科学]