过氧化物酶增殖物激活受体γ参与动脉粥样硬化机制研究进展  

Research progress on the mechanism of peroxisome proliferators activated receptors gamma in atherosclerosis

作　　者：赵楠[1] 李春梅[1] 丁查文 刘彬[1] 

机构地区：[1]哈尔滨医科大学附属第四医院神经内科,150081

出　　处：《国际免疫学杂志》2016年第5期506-509,共4页International Journal of Immunology

摘　　要：过氧化物酶增殖物激活受体γ（PPARγ）是核激素受体超家族的成员之一,是一种配体激活型转录因子,参与体内多种病理生理过程.近年研究表明,PPARγ在血管壁细胞和心肌细胞中表达,具有抗炎、抗氧化和抗增殖等多种作用.该受体激活后能调节动脉粥样硬化病理过程,参与动脉粥样硬化的免疫炎症机制,并可能对动脉粥样硬化的防治具有重要意义.研究PPARγ在动脉粥样硬化中的作用,以期对动脉粥样硬化的机制研究和免疫治疗提供理论依据.Peroxisome proliferators activated receptors gamma （PPARγ）,a member of the nuclear hormone receptor superfamily,is a ligand-activated transcription factor that is involved in various patho-physiological processes.Recent studies suggest that PPARγ,expressed in vessel wall cells and myocardial cells,has antiinflammatory,anti-oxidation,and anti-proliferation activities.When activated,this receptor could regulate the pathological process in artherosclerosis.It plays a role in the immune inflammatory mechanism of artherosclerosis,and it may be of significant importance for the management of artherosclerosis.

关 键 词：过氧化物酶增殖物激活受体Γ 动脉粥样硬化 

分 类 号：R692.5[医药卫生—泌尿科学]