蒙脱土负载碘催化合成双吲哚甲烷衍生物  

Synthesis of Bis( indolyl) alkane Derivatives Catalyzed By I_2 loaded Montmorillonite

作　　者：吴小云[1] 尹晓刚[1] 龚维[1] 王野[1] 陈卓[1] 

机构地区：[1]贵州师范大学化学与材料科学学院贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《合成化学》2016年第11期959-962,共4页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21362006);贵州省科技创新人才团队建设项目(黔科合人才团队[2014]4006号);贵州省科技合作项目(黔科合LH字[2016]7218号);贵州省科技厅科技支撑项目(黔科合支撑[2016]2311)

摘　　要：以蒙脱土负载碘(MMT/I2)作催化剂,醛(1a^1g)与吲哚(2)反应合成双吲哚甲烷衍生物(3a^3g),其结构经1H NMR和IR确证。以3a的合成为例,研究了催化剂、溶剂、反应时间、温度和物料比r[n(1)∶n(2)]对3产率的影响。结果表明:在最佳合成条件(2 1 mmol,r=1.1∶2.0,10 mol%MMT/I2,乙腈1 m L,于25℃反应5min)下,3a^3g产率67.9%~96.2%。MMT/I2循环使用3次,3a产率78.6%。A series of bis （indolyl）alkane derivatives （3a - 3g） were synthesized by the reaction of aldehydes（ 1a - 1g） with indole（2）, using 12 loaded montmorillonite（ MMT/I2 ） as catalyst. The structures were confirmed by 1H NMR and IR. Effects of catalyst, solvent, reaction time, reaction temperature and mole ratio r[ n （1） ：n（2） ] were investigated, using synthesis of 3a as the template reaction. The yields of 3a - 3g were 67.9% -96. 2% under the optimum conditions（2 1 mmol, r = 1.1：2. 0, 10 mol% MMT/I2, acetonitrile 1 mL, reaction at 25 ℃ for 5 min）. The yield of 3a was 78.6% after MMT/I2 recycle for three times.

关 键 词：蒙脱土负载碘 催化 双吲哚甲烷衍生物 合成 

分 类 号：O621.3[理学—有机化学] O626.1[理学—化学]